Document Detail

Effects of alveolar macrophage conditioned media from interstitial lung disease patients on the procollagen mRNA expression in human lung fibroblasts.
MedLine Citation:
PMID:  9206114     Owner:  NLM     Status:  MEDLINE    
Progressive inflammation and fibrosis are the central processes in the pathogenesis of pulmonary fibrosis. It is believed that macrophages in areas of chronically inflamed lung play a key role in fibrotic response. Therefore, we investigated the effects of alveolar macrophage (Am phi) conditioned media from interstitial lung disease (ILD) patients on lung fibroblast proliferation and procollagen mRNA expression. After stimulating with Am phi conditioned media from ILD patients, the fibroblast proliferation increased 71.4% compared with the control, but for media from bronchial carcinoma (BC) patients, it just increased 14.3%. There is a significant difference between the two groups (P < 0.05). The procollagen alpha, (I) mRNA in fibroblasts stimulated with Am phi conditioned media from ILD patients was increased 21.3%, and alpha 1 (III) was 37.2% higher than control (P < 0.05). It increased 6.8% and 12.8% for media from BC patients respectively, but there was no difference when compared to the control. We considered that Am phi from ILD patients might be in an activated state and could release some growth factors to stimulate fibroblast proliferation and promote collagen DNA expression.
Z Guo; Y Zhu; B Lui; Y Zhu; W Zhao; Y Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chinese medical sciences journal = Chung-kuo i hsüeh k'o hsüeh tsa chih / Chinese Academy of Medical Sciences     Volume:  11     ISSN:  1001-9294     ISO Abbreviation:  Chin. Med. Sci. J.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1997-08-04     Completed Date:  1997-08-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9112559     Medline TA:  Chin Med Sci J     Country:  CHINA    
Other Details:
Languages:  eng     Pagination:  25-7     Citation Subset:  IM    
Department of Internal Medicine, PUMC Hospital, Beijing.
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MeSH Terms
Carcinoma, Bronchogenic / pathology
Cell Division
Cells, Cultured
Culture Media, Conditioned
Fibroblasts / metabolism
Lung Diseases, Interstitial / pathology*
Lung Neoplasms / pathology
Macrophages, Alveolar / immunology*
Procollagen / genetics*
RNA, Messenger / biosynthesis*
Reg. No./Substance:
0/Culture Media, Conditioned; 0/Procollagen; 0/RNA, Messenger

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