| Effects of aluminum on the mechanical and electrical activity of the Langendorff-perfused rat heart. | |
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MedLine Citation:
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PMID: 8173535 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of aluminum (Al3+) chloride (1, 5, 10, 50 and 100 microM) on myocardial electromechanical activity was studied in 10 Langendorff-perfused hearts from adult female Wistar rats. Al3+ decreased the development of isovolumic systolic pressure from 34.3 +/- 2.95 mmHg under control conditions to 11.8 +/- 1.53 mmHg at 100 microM AlCl3 (P < 0.01) (diastolic pressure = 0 mmHg). The atrial and ventricular rates also decreased, but only with AlCl3 concentrations greater than 1 microM (from 180 +/- 5 to 94 +/- 11 bpm for atrial rate and from 180 +/- 5 to 78 +/- 7 bpm for ventricular rate). Reduction of coronary flow was also observed, reaching 60% at 100 microM Al3+. A delay in atrioventricular conduction occurred at 10 microM Al3+, increasing progressively up to 100 microM (62.3 +/- 4 ms in the Al(3+)-free solution to 143 +/- 34 ms in the presence of 100 microM Al3+, P < 0.01, ANOVA). QRS duration did not change as a function of increasing Al3+ concentrations (37.1 +/- 1.7 ms in the Al(3+)-free solution vs 32.1 +/- 1.6 ms in the presence of 100 microM Al3+). No qualitative changes in ECG were observed. These data show that the toxic effects of Al3+ on the myocardium are reflected in reduced systolic pressure development and coronary flow and increased PR interval. These effects are discussed in terms of the inhibition of nucleotide hydrolysis by Al3+. |
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Authors:
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M G Gomes; C A Moreira; J G Mill; L Massaroni; E M Oliveira; I Stefanon; D V Vassallo |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] Volume: 27 ISSN: 0100-879X ISO Abbreviation: Braz. J. Med. Biol. Res. Publication Date: 1994 Jan |
Date Detail:
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Created Date: 1994-06-06 Completed Date: 1994-06-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8112917 Medline TA: Braz J Med Biol Res Country: BRAZIL |
Other Details:
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Languages: eng Pagination: 95-100 Citation Subset: IM |
Affiliation:
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Departamento de Ciências Fisiológicas, Universidade Federal do Espírito Santo, Vitória, Brasil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aluminum
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pharmacology* Animals Blood Pressure / drug effects Chlorides / pharmacology* Coronary Circulation / drug effects Electrocardiography / drug effects Female Heart / drug effects*, physiology Osmolar Concentration Perfusion Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Chlorides; 7429-90-5/Aluminum |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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