Document Detail

Effects of altering infusion parameters on intimal hyperplasia following local catheter-based delivery into the rabbit iliac artery.
MedLine Citation:
PMID:  14709359     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Efficient local gene or drug therapy requires optimized application modalities to avoid vessel damage, which might lead to increased neointimal hyperplasia. Aim of the study was to evaluate different application parameters for local delivery using the channeled balloon catheter in order to minimize vessel trauma induced by local application. METHODS AND RESULTS: Sixty cholesterol fed rabbits were randomly enrolled into twelve groups of different local application parameters: group I, application pressure 2atm/application volume 1ml physiologic saline; group II, 2atm/2ml; group III, 2atm/5ml; group IV, 4atm/1ml; group V, 4atm/2ml; group VI, 4atm/5ml. The other six groups received Ringer's solution instead of saline. Administration of the solution was randomly performed in one iliac artery using the channeled balloon catheter with simultaneous balloon angioplasty (8atm). The contralateral iliac artery served as a control and was treated with balloon angioplasty only. Four weeks after local therapy, calibrated angiography was performed; the animals were sacrificed, vessel segments were excised and quantitative morphometric measurements were obtained. In none of the animals acute complications, e.g. dissection, thrombosis or perforation of the vessel, was noted. Up to an application pressure of 4atm and an application volume of 5ml, no significant neointima formation was seen compared to arteries which underwent angioplasty only. Additionally, no significant differences between saline and Ringer's solution were detected. In a multivariate analysis, neither application pressure nor volume were found to have a statistically significant influence on the amount of neointimal hyperplasia. CONCLUSIONS: Local application of "drugs" using the channeled balloon catheter is safe and feasible without significant induction of neointimal hyperplasia compared to angioplasty, if an application volume of 5ml and a pressure of 4atm is not exceeded.
Marc Kalinowski; Heiko Alfke; Christine Hamann; Kerstin Viehofer; Klaus Jochen Klose; James J Barry; Hans-Joachim Wagner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Atherosclerosis     Volume:  172     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-07     Completed Date:  2004-05-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  71-8     Citation Subset:  IM    
Department of Diagnostic Radiology, Philipps-University Hospital, Baldingerstrasse, 35033, Marburg, Germany.
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MeSH Terms
Angioplasty, Balloon
Balloon Dilatation
Drug Delivery Systems / adverse effects,  methods*
Hypercholesterolemia / pathology
Iliac Artery
Multivariate Analysis
Random Allocation
Tunica Intima / pathology*

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