| Effects of alpha- and beta-tigogenin cellobiosides on cholesterol absorption. | |
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MedLine Citation:
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PMID: 3445279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have synthesized alpha- and beta-anomers of tigogenin cellobioside and have determined their effects on intestinal absorption of [1,2-3H]cholesterol in rats. We demonstrated that the loss of tritium label likely to occur in the conversion of cholesterol to coprostanone was minimal. Dose response studies showed that both anomers depressed intestinal absorption of cholesterol but the depression was greater with the beta-anomer. |
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Authors:
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M R Malinow; J O Gardner; J T Nelson; P McLaughlin; B Upson; R Aigner-Held |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Steroids Volume: 48 ISSN: 0039-128X ISO Abbreviation: Steroids Publication Date: 1986 Sep-Oct |
Date Detail:
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Created Date: 1988-05-05 Completed Date: 1988-05-05 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0404536 Medline TA: Steroids Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 197-211 Citation Subset: IM |
Affiliation:
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Laboratory of Cardiovascular Diseases, Oregon Regional Primate Research Center, Beaverton 97006. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cholesterol / pharmacokinetics* Dose-Response Relationship, Drug Intestinal Absorption / drug effects* Isomerism Magnetic Resonance Spectroscopy Male Rats Rats, Inbred Strains Spirostans / pharmacology* Tritium |
| Grant Support | |
ID/Acronym/Agency:
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HL-16587/HL/NHLBI NIH HHS; RR-00163/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Spirostans; 10028-17-8/Tritium; 57-88-5/Cholesterol; 82597-74-8/sarsasapogenin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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