Document Detail

Effects of alpha-adrenoceptor antagonists and clonidine on the haemodynamic response to acute hypovolaemia in conscious rabbits.
MedLine Citation:
PMID:  1356797     Owner:  NLM     Status:  MEDLINE    
In conscious rabbits an inferior vena caval cuff was progressively inflated so cardiac output fell at a constant approximately 8% of its baseline value. There was a biphasic haemodynamic response, consisting of an initial compensatory phase during which there was progressive systemic vasoconstriction and tachycardia, followed by a decompensatory phase in which systemic vasoconstriction failed abruptly, blood pressure plummeted and heart rate declined. We tested the effects on the haemodynamic response of prior 4th ventricular, and in some cases intravenous, infusions of saline, yohimbine, clonidine, yohimbine plus clonidine, and bunazosin. From the results we conclude that a yohimbine-sensitive mechanism in the brainstem, possibly alpha 2-adrenoceptor-mediated, may be an essential element of the cardiac receptor-mediated decompensatory phase of acute central hypovolaemia, but does not contribute to the arterial baroreflex-mediated compensatory phase.
R G Evans; I P Hayes; J Ludbrook
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  216     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-11-13     Completed Date:  1992-11-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  265-72     Citation Subset:  IM    
University of Melbourne Department of Surgery, Parkville, Victoria, Australia.
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MeSH Terms
Adrenergic alpha-Antagonists / pharmacology*
Blood Pressure / drug effects*
Clonidine / administration & dosage,  pharmacology*
Drug Interactions
Heart Rate / drug effects*
Hemorrhage / physiopathology
Injections, Intravenous
Plasma Volume / drug effects*
Quinazolines / pharmacology
Yohimbine / administration & dosage,  pharmacology
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Quinazolines; 0/Vehicles; 146-48-5/Yohimbine; 4205-90-7/Clonidine; 80755-51-7/bunazosin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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