Document Detail


Effects of an alpha 2 antagonist in a 20-year-old Java monkey with MPTP-induced parkinsonian signs.
MedLine Citation:
PMID:  1678307     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The study attempted to verify whether activation of locus coeruleus neurons by alpha 2 antagonists might improve parkinsonian signs. Treatment with the racemic alpha 2 antagonist R 47 243 of a monkey with MPTP-induced parkinsonian signs normalized blink rate, reduced resting tremor, and improved several other parkinsonian signs. In a second experiment, the (-)-isomer R 62 651 produced a gradual change in tremor which was the inverse of the mannner in which tremor had become installed as the result of progression earlier upon the MPTP challenge. It is proposed that further research be conducted to determine whether alpha 2 antagonists may beneficially influence the progression of Parkinson's disease.
Authors:
F C Colpaert; A D Degryse; H V Van Craenendonck
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research bulletin     Volume:  26     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-09-17     Completed Date:  1991-09-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  627-31     Citation Subset:  IM    
Affiliation:
Department of Psychopharmacology, Janssen Pharmaceutica, Beerse, Belgium.
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MeSH Terms
Descriptor/Qualifier:
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Adrenergic alpha-Antagonists / pharmacology*
Animals
Blinking / drug effects
Locus Coeruleus / drug effects,  physiopathology*
Macaca fascicularis
Neurons / drug effects,  physiology*
Parkinson Disease, Secondary / chemically induced,  physiopathology*
Piperidines / pharmacology*
Thiazoles / pharmacology*
Tremor / physiopathology
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Piperidines; 0/Thiazoles; 104383-18-8/R 47243; 28289-54-5/1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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