| Effects of almond consumption on the reduction of LDL-cholesterol: a discussion of potential mechanisms and future research directions. | |
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MedLine Citation:
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PMID: 21457263 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Diet plays a seminal role in the prevention and treatment of cardiovascular disease. Consumption of tree nuts has been shown to reduce low-density lipoprotein cholesterol (LDL-C), a primary target for coronary disease prevention, by 3-19%. Almonds have been found to have a consistent LDL-C-lowering effect in healthy individuals, and in individuals with high cholesterol and diabetes, in both controlled and free-living settings. Almonds are low in saturated fatty acids, rich in unsaturated fatty acids, and contain fiber, phytosterols, and plant protein. Other cardioprotective nutrients unique to almonds include α-tocopherol, arginine, magnesium, copper, manganese, calcium, and potassium. Mechanisms responsible for the LDL-C reduction observed with almond consumption are likely associated with the nutrients almonds provide. Biologically active by nature, these nutrients target primary mechanistic routes of LDL-C reduction, including decreased (re)absorption of cholesterol and bile acid, increased bile acid and cholesterol excretion, and increased LDL-C receptor activity. The nutrients present in almonds may regulate enzymes involved in de novo cholesterol synthesis and bile acid production. Research is needed to understand all mechanisms by which almonds reduce cardiovascular disease risk. |
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Authors:
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Claire E Berryman; Amy Griel Preston; Wahida Karmally; Richard J Deckelbaum; Penny M Kris-Etherton |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nutrition reviews Volume: 69 ISSN: 1753-4887 ISO Abbreviation: Nutr. Rev. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376405 Medline TA: Nutr Rev Country: United States |
Other Details:
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Languages: eng Pagination: 171-85 Citation Subset: IM |
Copyright Information:
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© 2011 International Life Sciences Institute. |
Affiliation:
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Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA. Irving Institute for Clinical and Translational Research, Columbia University, New York, New York, USA. Institute of Human Nutrition, Columbia University Medical Center, New York, New York, USA. |
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