| Effects of allopurinol on the therapeutic efficacy of methotrexate. | |
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MedLine Citation:
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PMID: 1131828 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antitumor effects of methotrexate against early leukemia L1210 were partially reversed by the coadministration of allopurinol in vivo, even though allopurinol did not alter the growth-inhibitory effects of methotrexate against L1210 cells in culture. These data suggest that this alteration in antitumor activity results from a decreased catabolism of preformed systemic purines by allopurinol, a potent inhibitor of xanthine oxidase. On the other hand, the therapeutic effect of methotrexate against the P288 leukemia was not significantly altered by allopurinol did not significantly alter the toxicity of methotrexate that, in the mouse, the antileukemic effects of methotrexate are more related to a purineless rather than a thymineless death. |
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Authors:
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G B Grindey; R G Moran |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer research Volume: 35 ISSN: 0008-5472 ISO Abbreviation: Cancer Res. Publication Date: 1975 Jul |
Date Detail:
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Created Date: 1975-09-05 Completed Date: 1975-09-05 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 2984705R Medline TA: Cancer Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1702-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Allopurinol
/
administration & dosage,
pharmacology* Animals Chick Embryo Female Hypoxanthines / pharmacology Leukemia L1210 / drug therapy Leukemia, Experimental / drug therapy* Methotrexate / therapeutic use*, toxicity Mice Mice, Inbred DBA Thymidine / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Hypoxanthines; 315-30-0/Allopurinol; 50-89-5/Thymidine; 59-05-2/Methotrexate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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