Document Detail

Effects of allopurinol on the therapeutic efficacy of methotrexate.
MedLine Citation:
PMID:  1131828     Owner:  NLM     Status:  MEDLINE    
The antitumor effects of methotrexate against early leukemia L1210 were partially reversed by the coadministration of allopurinol in vivo, even though allopurinol did not alter the growth-inhibitory effects of methotrexate against L1210 cells in culture. These data suggest that this alteration in antitumor activity results from a decreased catabolism of preformed systemic purines by allopurinol, a potent inhibitor of xanthine oxidase. On the other hand, the therapeutic effect of methotrexate against the P288 leukemia was not significantly altered by allopurinol did not significantly alter the toxicity of methotrexate that, in the mouse, the antileukemic effects of methotrexate are more related to a purineless rather than a thymineless death.
G B Grindey; R G Moran
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer research     Volume:  35     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1975 Jul 
Date Detail:
Created Date:  1975-09-05     Completed Date:  1975-09-05     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1702-5     Citation Subset:  IM    
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MeSH Terms
Allopurinol / administration & dosage,  pharmacology*
Chick Embryo
Hypoxanthines / pharmacology
Leukemia L1210 / drug therapy
Leukemia, Experimental / drug therapy*
Methotrexate / therapeutic use*,  toxicity
Mice, Inbred DBA
Thymidine / pharmacology
Reg. No./Substance:
0/Hypoxanthines; 315-30-0/Allopurinol; 50-89-5/Thymidine; 59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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