Document Detail

Effects of alkylating agents on lymphocytes from controls and from patients with Fanconi's anemia. Studies of sister chromatid exchanges, chromosome aberrations, and kinetics of cell division.
MedLine Citation:
PMID:  89073     Owner:  NLM     Status:  MEDLINE    
The frequency of sister chromatid exchanges (SCE) and chromosome aberrations and the dynamics of cell division in peripheral blood lymphocytes of four patients with Fanconi's anemia were studied after in vitro exposure to alkylating agents TEPA and mitomycin. SCE frequency was significantly increased even after very low doses of mutagens, while chromosome aberrations were significantly increased only after high doses (0.160 micrograms/ml mitomycin and 10(-5) M TEPA). The responses of Fanconi's anemia cells and control cells did not differ significantly. The increased frequency of both SCE and chromosome aberrations was accompanied by gradual delay of cell division, which was most conspicuous in cells from patients with Fanconi's anemia.
B Novotná; P Goetz; N I Surkova
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Human genetics     Volume:  49     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1979 May 
Date Detail:
Created Date:  1979-10-24     Completed Date:  1979-10-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  41-50     Citation Subset:  IM    
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MeSH Terms
Anemia, Aplastic / blood*
Azirines / pharmacology*
Cell Division / drug effects
Chromatids / drug effects*
Chromosome Aberrations*
Crossing Over, Genetic / drug effects
Fanconi Anemia / blood*,  genetics
Lymphocytes / drug effects*,  ultrastructure
Mitomycins / pharmacology*
Triethylenephosphoramide / pharmacology*
Reg. No./Substance:
0/Azirines; 0/Mitomycins; 545-55-1/Triethylenephosphoramide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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