Document Detail

Effects of alkali-treated proteins: feeding studies with free and protein-bound lysinoalanine in rats and other animals.
MedLine Citation:
PMID:  9494     Owner:  NLM     Status:  MEDLINE    
To find out whether alkali-treated proteins posses nephrotoxic properties, feeding studies were conducted with drastically treated soybean protein and casein, and also with lysinoalanine (LAL), the amino acid known to be formed in protein subjected to high pH at elevated temperature. The feeding of synthesized LAL to rats at dietary levels of 100 ppm and above induced typical renal changes, called nephrocytomegalia. No such changes or any other indications of toxicity were observed, however, upon feeding much higher levels of LAL (up to 6,000 ppm) when provided as the protein-bound compound in alkali-treated casein or soybean protein. When set free by complete acid hydrolysis, LAL induced considerable renal activity, comparable to that of the synthetic compound. These results indicate that alkali treatment of proteins does not induce nephrotoxic properties provided that the compound remains protein-bound. Some nephrotoxic activity was observed, however, with peptide-boound LAL in break-down products (molecular weight less than 5,000) of alkali-treated casein, but considerably less than that of the free compound. LAL-analyses in blood, urine, and feces of rats fed free or protein-bound LAL indicated a positive correlation between intestinal absorption and nephrotoxic potential. No renal changes were encountered upon feeding diets with 1,000 ppm synthetic LAL to mice, hamsters, rabbits, quail, dogs or monkeys, which suggest a species specificity of LAL-induced renal changes in rats.
A P De Groot; P Slump; V J Feron; L Van Beek
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of nutrition     Volume:  106     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1976 Oct 
Date Detail:
Created Date:  1976-11-21     Completed Date:  1976-11-21     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1527-38     Citation Subset:  IM    
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MeSH Terms
Caseins* / toxicity
Dipeptides / toxicity*
Hydrogen-Ion Concentration
Kidney / drug effects*,  pathology
Macaca mulatta
Species Specificity
Vegetable Proteins* / toxicity
Reg. No./Substance:
0/Caseins; 0/Dipeptides; 0/Vegetable Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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