| EFFECTS OF ALISKIREN ON QT DURATION AND DISPERSION IN HYPERTENSIVE PATIENTS WITH TYPE 2 DIABETES MELLITUS. | |
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MedLine Citation:
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PMID: 22074122 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Aims: to evaluate the effect of aliskiren compared to amlodipine on QT duration and dispersion in hypertensive patients with type 2 diabetes. Materials and methods: 170 outpatients aged 50-75 years with mild to moderate hypertension (SBP > 130 and < 180 mmHg and DBP > 80 and < 100 mmHg) and type 2 diabetes were randomly treated with aliskiren 300 mg or amlodipine 10 mg, both given once daily for 24 weeks, according to a prospective, open label, blinded-end point, parallel group design. At the end of the placebo run-in and after 12 and 24 weeks of treatment BP measurements (by mercury sphygmomanometer, Korotkoff I and V), plasma biochemistry and a standard 12-lead surface ECG were evaluated. Results: both aliskiren and amlodipine significantly reduced SBP/DBP values (-27.2/-14.3 mmHg, p< 0.001 vs placebo and -27.8/-14.2 mmHg, p< 0.001 vs placebo, respectively), with no statistical difference between the two drugs. Aliskiren, but not amlodipine, significantly reduced maximum QT interval (QTmax) (-14 ms at 12 weeks and -17 ms at 24 weeks, both p< 0.05 vs placebo) and corrected QT max (QTc max) (-26 ms and -31 ms, p< 0.01) as well as the dispersion of both QT (-11 ms and -13 ms, p< 0.01) and QTc (-18 ms and -19 ms, p< 0.01). Conclusions: despite similar BP lowering effect, aliskiren, but not amlodipine, reduced QT duration and dispersion, which might be related to the ability of aliskiren to interfere with mechanisms underlying myocardial electrical instability in the heart of diabetic hypertensive patients. |
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Authors:
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Roberto Fogari; Annalisa Zoppi; Pamela Maffioli; Claudio Monti; Pierangelo Lazzari; Amedeo Mugellini; Giuseppe Derosa |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-10 |
Journal Detail:
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Title: Diabetes, obesity & metabolism Volume: - ISSN: 1463-1326 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883645 Medline TA: Diabetes Obes Metab Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2011 Blackwell Publishing Ltd. |
Affiliation:
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Department of Internal Medicine and Therapeutics, Centro Ipertensione e Fisiopatologia Cardiovascolare, University of Pavia, Pavia, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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