Document Detail

Effects of alcohol withdrawal on 24 hour ambulatory blood pressure among alcohol-dependent patients.
MedLine Citation:
PMID:  14691389     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although epidemiologic studies have reported an association between alcohol intake and high blood pressure (BP), the results of intervention studies have shown inconsistent results. We embarked on a study to determine whether different subgroups of alcohol-dependent patients may be identified in relation to the effect of alcohol on BP. METHODS: Fifty alcohol-dependent men (mean age, 41.4 years) received 0.4 g of ethanol per kilogram of body weight every 4 hr in 200 ml of orange juice during 24 hr and the same amount of orange juice without ethanol during another 24 hr. Twenty-four hour ambulatory BP monitoring was performed during ethanol and orange juice intakes, as was hormonal and biochemical analysis. RESULTS: Thirty-five (75%) alcohol-dependent men were normotensive and 15 (30%) hypertensive. Eighteen (51%) normotensive and 12 (80%) hypertensive subjects showed a significant decrease in 24 hr mean BP after ethanol withdrawal (mean decrease of 8.4 mm Hg [95% confidence interval, -11.2 to -5.7] and 12.5 mm Hg [confidence interval, -16.2 to -8.8], respectively) and were considered as sensitive to alcohol. The remaining alcohol-dependent subjects were considered as resistant to alcohol. Normotensive subjects sensitive to ethanol showed a significantly greater left ventricular mass and a significantly lower ejection fraction than those normotensive patients whose BP did not change after ethanol withdrawal (both p < 0.01). CONCLUSIONS: More than three fourths of the hypertensive and more than half of the normotensive alcohol-dependent patients showed sensitivity to the pressor effects of ethanol. Impairment also was observed in heart function in normotensive patients sensitive to the pressor effects of ethanol.
Ramón Estruch; Emilio Sacanella; Alejandro De la Sierra; María Teresa Aguilera; Emília Antúnez; José M Nicolás; Joaquín Fernández-Solá; Antonio Coca; Alvaro Urbano-Márquez
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Alcoholism, clinical and experimental research     Volume:  27     ISSN:  0145-6008     ISO Abbreviation:  Alcohol. Clin. Exp. Res.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-23     Completed Date:  2004-08-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7707242     Medline TA:  Alcohol Clin Exp Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2002-8     Citation Subset:  IM    
Alcohol Unit, Department of Internal Medicine, Hospital Clínic, University of Barcelona, Institut de Investigacions Biomèdiques August Pi i Sunyer, Spain.
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MeSH Terms
Alcoholism / physiopathology*
Analysis of Variance
Blood Pressure / drug effects,  physiology*
Blood Pressure Monitoring, Ambulatory / methods,  statistics & numerical data*
Chi-Square Distribution
Confidence Intervals
Cross-Sectional Studies
Ethanol / pharmacology
Hypertension / physiopathology*
Middle Aged
Prospective Studies
Statistics, Nonparametric
Substance Withdrawal Syndrome / physiopathology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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