Document Detail


Effects of alcohol and smoking during pregnancy on infant autonomic control.
MedLine Citation:
PMID:  19253344     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prenatal exposure to smoking and alcohol increases the risk for Sudden Infant Death Syndrome (SIDS). Physiological changes associated with these exposures are not well studied. Full-term infants were tested within the first 3 days of life. We hypothesized that maternal alcohol consumption and/or smoking during pregnancy would alter autonomic nervous system function. Newborns whose mothers smoked during pregnancy had lower beat-to-beat heart rate variability in quiet sleep. Infants whose mothers consumed alcohol had lower global heart rate variability, but only in active sleep. Unexposed infants demonstrated increases in heart rate with head-up tilt and decreases in heart rate with head-down tilt, but smoking and alcohol-exposed infants showed no significant responses. These results indicate that autonomic function is altered by prenatal exposure to alcohol and smoking. Such markers may provide early identification of infants at greatest risk for SIDS.
Authors:
William P Fifer; Sherri Ten Fingers; Mitzi Youngman; Esperanza Gomez-Gribben; Michael M Myers
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Developmental psychobiology     Volume:  51     ISSN:  1098-2302     ISO Abbreviation:  Dev Psychobiol     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-16     Completed Date:  2009-07-07     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  0164074     Medline TA:  Dev Psychobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  234-42     Citation Subset:  IM    
Copyright Information:
(c) 2009 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcohol Drinking / adverse effects*
Autonomic Nervous System / physiopathology*
Birth Weight / physiology
Electrocardiography
Female
Heart Rate / physiology
Hematocrit
Homeostasis / physiology
Humans
Infant, Newborn
Pregnancy
Prenatal Exposure Delayed Effects / physiopathology*
Prone Position / physiology
Pulmonary Ventilation / physiology
Reference Values
Risk Factors
Signal Processing, Computer-Assisted
Sudden Infant Death / etiology*
Tilt-Table Test
Tobacco Smoke Pollution / adverse effects*
Grant Support
ID/Acronym/Agency:
R37 HD032774/HD/NICHD NIH HHS; R37 HD032774/HD/NICHD NIH HHS; R37 HD032774-12/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Tobacco Smoke Pollution
Comments/Corrections
Comment In:
Dev Psychobiol. 2009 Apr;51(3):213-4   [PMID:  19206137 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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