Document Detail

Effects of alcohol on hemodynamic and cardiovascular reaction in different genotypes.
MedLine Citation:
PMID:  15936929     Owner:  NLM     Status:  MEDLINE    
This study assessed hemodynamic changes associated with alcohol intake in people who have different sensitivities to alcohol due to an inactive form of mitochondrial aldehyde dehydrogenase (ALDH). People with ALDH2*1/*2 are more sensitive to alcohol than people with ALDH2*1/*1. Six ALDH2*1/*1 subjects and four ALDH2*1/*2 subjects participated in this study. The subjects drank whisky with water (0.4 ml/kg of ethanol). Optical topography (Hitachi Medical Corporation: ETG-100) was used to measure hemodynamic changes in an occipital region during visual stimulation. Hemodynamic changes, heart rate, mean blood pressure, and reaction time were measured 20 min before, immediately after, and 20, 40, and 60 min after alcohol intake. Breath-alcohol concentration was measured at each of the assessment points. After alcohol intake, the hemodynamic peak value, peak time, reaction time, and heart rate of the ALDH2*1/*2 subjects differed from those of the ALDH2*1/*1 subjects. The hemodynamic peak value and reaction time gradually increased 60 min after alcohol exposure, and the peak time was shortest 20 min after alcohol intake. These results might reflect different acetaldehyde levels causing changes in the reactivity of the vascular smooth muscle and cerebral activity in the visual cortex.
Akiko Obata; Kanehisa Morimoto; Hiroki Sato; Tatsuya Takeshita; Hideo Kawaguchi; Hideaki Koizumi; Atsushi Maki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychiatry research     Volume:  139     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-06-20     Completed Date:  2005-10-06     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  65-72     Citation Subset:  IM    
Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan.
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MeSH Terms
Aldehyde Dehydrogenase / genetics*
Blood Pressure / drug effects*
Central Nervous System Depressants / pharmacology*
Ethanol / administration & dosage,  pharmacology*
Heart Rate / drug effects*
Hemodynamics / drug effects
Reaction Time / drug effects*
Reg. No./Substance:
0/Central Nervous System Depressants; 64-17-5/Ethanol; EC protein, human; EC Dehydrogenase
Erratum In:
Psychiatry Res. 2005 Aug 30;139(3):275

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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