| Effects of alcohol-free beer on lipid profile and parameters of oxidative stress and inflammation in elderly women. | |
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MedLine Citation:
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PMID: 18947976 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We assessed the influence of alcohol-free beer on factors implicated in atherosclerosis, such as lipid profile, oxidative stress parameters, and proinflammatory cytokines, in postmenopausal women, a population particularly at risk for atherosclerotic disease. METHODS: The study was carried out in 29 nuns, 58 to 73 y old, who live in a convent with a disciplined, regular, and homogeneous lifestyle. The nuns maintained their habits and diet routine, but their meals were supplemented with 500 mL/d of alcohol-free beer (0.0%) divided into two doses over a 45-d period. Lipid profile, inflammatory markers such as C-reactive protein, interleukins 1 and 6, and tumor necrosis factor-alpha, and parameters of oxidative metabolism were determined before and after the study period. RESULTS: There were no differences in the levels of C-reactive protein and proinflammatory cytokines after diet supplementation. The antibody titers to oxidized low-density lipoprotein were significant lower (P < 0.05), and thiobarbituric acid-reactive substances (-18%, P < 0.001) and plasma carbonyl group content (-21%, P < 0.001) were decreased when compared with initial values. Increases in alpha-tocopherol levels (+9%, P < 0.05) and erythrocytic glutathione levels (+29%, P < 0.001) were also noted. With respect to lipid profile, only subjects with cholesterol levels higher than 240 mg/dL showed lower levels after supplementation. CONCLUSION: Consumption of non-alcoholic beer produces a decrease in oxidative stress that can have a beneficial impact on cardiovascular risk; however, the circulating concentrations of inflammatory mediators involved in its pathophysiology remained unchanged. |
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Authors:
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Jesús Román Martínez Alvarez; Victoria Valls Bellés; Ana Belén López-Jaén; Antonio Villarino Marín; Pilar Codoñer-Franch |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-10-23 |
Journal Detail:
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Title: Nutrition (Burbank, Los Angeles County, Calif.) Volume: 25 ISSN: 0899-9007 ISO Abbreviation: Nutrition Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-19 Completed Date: 2009-04-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8802712 Medline TA: Nutrition Country: United States |
Other Details:
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Languages: eng Pagination: 182-7 Citation Subset: IM |
Affiliation:
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Spanish Society of Dietetics and Food Science, Madrid, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Beer* Beverages Biological Markers / blood C-Reactive Protein / metabolism Cardiovascular Diseases / blood, epidemiology, prevention & control Ethanol / administration & dosage Female Humans Inflammation / blood* Inflammation Mediators / blood* Interleukins / blood Lipid Peroxidation Lipids / blood* Middle Aged Oxidation-Reduction Oxidative Stress / drug effects* Postmenopause / blood Thiobarbituric Acid Reactive Substances / metabolism Tumor Necrosis Factor-alpha / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Inflammation Mediators; 0/Interleukins; 0/Lipids; 0/Thiobarbituric Acid Reactive Substances; 0/Tumor Necrosis Factor-alpha; 64-17-5/Ethanol; 9007-41-4/C-Reactive Protein |
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