Document Detail


Effects of airway pressure on bronchial blood flow.
MedLine Citation:
PMID:  3549675     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the effects of increased airway pressure caused by increasing levels of positive end-expiratory pressure (PEEP) on bronchial arterial pressure-flow relationships. In eight alpha-chloralose-anesthetized mechanically ventilated sheep (23-27 kg), the common bronchial artery, the bronchial branch of the bronchoesophageal artery, was cannulated and perfused with a pump. The control bronchial blood flow (avg 12 +/- 1 ml/min or 0.48 ml X min-1 X kg-1) was set to maintain mean bronchial arterial pressure equal to systemic blood pressure. Pressure-flow curves of the bronchial circulation were measured by making step changes in bronchial blood flow, and changes in these curves were analyzed with measurements of the pressure at zero flow and the slope of the linearized curve. The zero-flow pressure represents the effective downstream pressure, and the slope represents the resistance through the bronchial vasculature. At a constant bronchial arterial pressure of 100 mmHg, an 8 mmHg increase in mean airway pressure caused a 40% reduction in bronchial blood flow. Under constant flow conditions, increases in mean airway pressure with the application of PEEP caused substantial increases in bronchial arterial pressure, averaging 4.6 mmHg for every millimeters of mercury increase in mean airway pressure. However, bronchial arterial pressure at zero flow increased approximately one-for-one with increases in mean airway pressure. Thus the acute sensitivity of the bronchial artery to changes in mean airway pressure results primarily from changes in bronchovascular resistance and not downstream pressure.
Authors:
E M Wagner; W A Mitzner; E R Bleecker
Related Documents :
19228985 - Interacting effects of genioglossus stimulation and mandibular advancement in sleep apnea.
7702145 - A new laryngeal mask prototype. preliminary evaluation of seal pressures and glottic is...
7610315 - Platelet function and fibrinolytic activity in hypertensive and normotensive sleep apne...
18564805 - Comparison of the laryngeal mask (lma) and laryngeal tube (lt) with the perilaryngeal a...
24965685 - Consciously controlled breathing decreases the high-frequency component of heart rate v...
8287805 - Cerebral hyperperfusion following episodes of bradycardia in the preterm infant.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  62     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1987 Feb 
Date Detail:
Created Date:  1987-05-18     Completed Date:  1987-05-18     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  561-6     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure
Bronchi / blood supply*
Positive-Pressure Respiration*
Regional Blood Flow
Sheep

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Influence of inspiratory assistance on ventilatory control during moderate exercise.
Next Document:  Effect of endotoxin on diaphragm lymph contamination in unanesthetized sheep.