Document Detail

Effects of airway parasympathetic tone on responses to intravenous bronchoconstrictor agonists in rats.
MedLine Citation:
PMID:  7896609     Owner:  NLM     Status:  MEDLINE    
To test the hypothesis that parasympathetic airway tone may affect airway responsiveness, we measured bronchoconstrictor responses to intravenous bethanechol (BCh) in anesthetized vagotomized rats with and without background vagal nerve stimulation and developed a predictive model based on pharmacological additivity between endogenous and intravenous agonists. A high degree of agreement (r2 = 0.93) between the measured and predicted responses indicated that intravenous BCh and parasympathetic tone had bronchoconstrictor effects that were pharmacologically additive. An expansion of the additive model was used to determine that the percentage of decrease in respiratory system conductance (Grs) would be a measure of airway response independent of background parasympathetic tone. As predicted, the percentage of decrease in Grs after intravenous BCh was minimally affected by background vagal stimulation. However, the percentage of decrease in Grs was augmented by vagal stimulation for intravenous 5-hydroxytryptamine hydrochloride, a known parasympathetic neuromodulator, and for methacholine, an agonist with nicotinic as well as muscarinic activity (P < 0.02 for each agonist). We conclude that airway parasympathetic tone can be a source of variability for airway responsiveness when substances having neuromodulatory activity are involved in the provocative challenge.
R Sorkness; J Clough; R F Lemanske
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  77     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-04-21     Completed Date:  1995-04-21     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2698-702     Citation Subset:  IM    
School of Pharmacy, University of Wisconsin, Madison 53792.
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MeSH Terms
Bethanechol / pharmacology
Bronchoconstrictor Agents / pharmacology*
Electric Stimulation
Injections, Intravenous
Models, Biological
Parasympathetic Nervous System / physiology*
Rats, Inbred Strains
Respiratory System / drug effects*,  innervation*
Vagus Nerve / physiology
Grant Support
Reg. No./Substance:
0/Bronchoconstrictor Agents; 674-38-4/Bethanechol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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