| Effects of air transportation cause physiological and biochemical changes indicative of stress leading to regulation of chaperone expression levels and corticosterone concentration. | |
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MedLine Citation:
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PMID: 19151507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Laboratory animals generally experience numerous unfamiliar environmental and psychological influences such as noises, temperatures, handling, shaking, and smells during the process of air transportation. To investigate whether stress induced by air transportation affects stress-related factors in animals, the levels of hormone and chaperone protein were measured in several tissues of F344 rats transported for 13 h and not transported. Herein, we conclude that the levels of corticosterone, HSP70, and GRP78 were significantly increased in the transported group compare to not transported group, but they were rapidly restored to the not transported group level after a recovery period of one week. However, the magnitude of induction and restoration levels of these factors varied depending on the tissue type. Thus, these results suggest that air transportation should be considered for the improvement of laboratory animal health and to reduce the incidence of laboratory animal stress. |
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Authors:
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SunBo Shim; SeHyun Lee; ChuelKyu Kim; ByoungGuk Kim; SeungWan Jee; SuHae Lee; JiSoon Sin; ChangJoon Bae; Jong-Min Woo; JungSik Cho; EonPil Lee; HaeWook Choi; HongSung Kim; JaeHo Lee; YoungJin Jung; ByungWook Cho; KabRyong Chae; DaeYoun Hwang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Experimental animals / Japanese Association for Laboratory Animal Science Volume: 58 ISSN: 1881-7122 ISO Abbreviation: Exp. Anim. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-01-19 Completed Date: 2009-04-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9604830 Medline TA: Exp Anim Country: Japan |
Other Details:
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Languages: eng Pagination: 11-7 Citation Subset: IM |
Affiliation:
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Laboratory Animal Resources Team, National Institute of Toxicological Research, Korean FDA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aerospace Medicine* Aircraft Animals Behavior, Animal Corticosterone / blood* Female HSP70 Heat-Shock Proteins / blood* Heat-Shock Proteins / blood* Male Molecular Chaperones / blood* Rats Rats, Inbred F344 Sex Factors Stress, Psychological / blood*, etiology |
| Chemical | |
Reg. No./Substance:
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0/HSP70 Heat-Shock Proteins; 0/Heat-Shock Proteins; 0/Molecular Chaperones; 0/molecular chaperone GRP78; 50-22-6/Corticosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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