Document Detail

Effects of air pollution on blood pressure and heart rate variability: a panel study of vehicular traffic controllers in the city of São Paulo, Brazil.
MedLine Citation:
PMID:  15618077     Owner:  NLM     Status:  MEDLINE    
AIMS: Evaluating the effects of air pollution on Sao Paulo city's vehicular traffic controllers by means of risk indicators for cardiovascular diseases. METHODS AND RESULTS: Twenty-four hour blood pressure recordings and an electrocardiogram were obtained in 48 healthy, non-smoking vehicular traffic controllers, aged 31-55 years, during three periods: winter 2000, summer 2001, and winter 2001. Effects of air pollutants on the outcomes were estimated using linear regression based on generalized estimated equations, controlling for age, body mass index, humidity, and temperature. An interquartile range (IQR) increase in CO (1.1 p.p.m.) was associated with increases of 2.6 mmHg (95% CI 1.0, 4.2), 1.8 mmHg (95% CI 0.8, 2.8), and 2.4 mmHg (95% CI 1.1, 3.6) in systolic, diastolic, and mean 24 h ambulatory blood pressures. SO(2) also had relevant effects on blood pressure. On heart rate variability, an IQR increase of SO2 (9.6 microg/m3) was negatively associated with the standard deviation (SD) of normal RR intervals (SDNN) -7.93 ms (95% CI -15.3, -0.6). CONCLUSION: This study supplies biological plausibility for observational studies on air pollution-related cardiovascular morbidity and mortality.
Ubiratan de Paula Santos; Alfésio Luís Ferreira Braga; Dante Marcelo Artigas Giorgi; Luiz Alberto Amador Pereira; César Jose Grupi; Chin An Lin; Marcos Antonio Bussacos; Dirce Maria Trevisan Zanetta; Paulo Hilário do Nascimento Saldiva; Mario Terra Filho
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-12-03
Journal Detail:
Title:  European heart journal     Volume:  26     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-24     Completed Date:  2005-05-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  England    
Other Details:
Languages:  eng     Pagination:  193-200     Citation Subset:  IM    
Divisão de Pneumologia, Instituto do Coração (InCor), Av. Dr Enéas de Carvalho Aguiar, 44, CEP 05403-000, São Paulo, SP, Brazil.
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MeSH Terms
Air Pollutants / analysis,  toxicity*
Air Pollution / adverse effects*,  analysis
Blood Pressure / drug effects*,  physiology
Brazil / epidemiology
Cardiovascular Diseases / epidemiology
Heart Rate / drug effects*,  physiology
Middle Aged
Nitric Oxide / analysis,  toxicity
Risk Factors
Sulfur Dioxide / analysis,  toxicity
Reg. No./Substance:
0/Air Pollutants; 10102-43-9/Nitric Oxide; 7446-09-5/Sulfur Dioxide

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