Document Detail

Effects of aging and smoking on carotid intima-media thickness in HIV-infection.
MedLine Citation:
PMID:  22874518     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To investigate the effects of aging and smoking on carotid intima-media thickness (cIMT) among patients with and without HIV.
METHODS: Data from a community sample of HIV-infected and HIV-uninfected participants were analyzed. Carotid intima-media thickness was measured via carotid ultrasound and smoking history was obtained via patient interview.
RESULTS: Data on 166 male and female participants with stable HIV-infection and 152 healthy HIV-uninfected participants were analyzed. Among the HIV-infected and HIV-uninfected participants, a significant association was observed between age and cIMT [r = 0.51, P < 0.0001 (HIV), r = 0.39, P < 0.0001, (non-HIV)], and between smoking burden and cIMT [r = 0.42, P < 0.0001 (HIV), r = 0.24, P = 0.003 (non-HIV)]. In multivariate regression modeling among all participants (HIV and non-HIV), a significant three-way interaction was observed between age, smoking burden, and HIV status with respect to cIMT (P < 0.010), controlling for sex, race, and traditional cardiovascular disease (CVD) risk factors, such that increased cIMT was associated with increased smoking burden and age to a greater degree among HIV-infected vs. HIV-uninfected participants. Among HIV-infected participants a significant interaction between smoking burden and age with respect to cIMT was seen (P = 0.027) controlling for race, sex, CVD risk factors, immunological function, and antiretroviral therapy use.
CONCLUSION: A significant interaction between HIV, age, and smoking on cIMT was observed, suggesting that HIV-infection modifies the relationship of age and smoking on cIMT in this population. These findings emphasize the need to encourage smoking cessation in this population, due to its deleterious effect on subclinical atherosclerosis in older HIV-infected patients.
Kathleen V Fitch; Sara E Looby; Alison Rope; Peace Eneh; Linda Hemphill; Hang Lee; Steven K Grinspoon
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  AIDS (London, England)     Volume:  27     ISSN:  1473-5571     ISO Abbreviation:  AIDS     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-12     Completed Date:  2013-06-17     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  8710219     Medline TA:  AIDS     Country:  England    
Other Details:
Languages:  eng     Pagination:  49-57     Citation Subset:  IM; X    
Massachusetts General Hospital (MGH) Program in Nutritional Metabolism, Boston, MA 02114, USA.
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MeSH Terms
Aging / pathology*
Atherosclerosis / blood,  etiology,  pathology*
Carotid Intima-Media Thickness*
Cholesterol, HDL / blood
Cholesterol, LDL / blood
HIV Infections / blood,  drug therapy,  pathology*
Massachusetts / epidemiology
Middle Aged
Regression Analysis
Risk Factors
Smoking / adverse effects*,  blood,  pathology*
Triglycerides / blood
Grant Support
1 UL1 RR025758-01/RR/NCRR NIH HHS; K23 NR011833/NR/NINR NIH HHS; K23 NR011833-01A1/NR/NINR NIH HHS; K24 DK064545/DK/NIDDK NIH HHS; K24 DK064545-08/DK/NIDDK NIH HHS; M01 RR000083/RR/NCRR NIH HHS; M01-RR-01066/RR/NCRR NIH HHS; P30 DK040561/DK/NIDDK NIH HHS; R01 DK049302/DK/NIDDK NIH HHS; R01 DK049302/DK/NIDDK NIH HHS; UL1 RR025758/RR/NCRR NIH HHS
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Triglycerides

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