Document Detail


Effects of aging and exercise training on skeletal muscle blood flow and resistance artery morphology.
MedLine Citation:
PMID:  23042906     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
With old age, blood flow to the high-oxidative red skeletal muscle is reduced and blood flow to the low-oxidative white muscle is elevated during exercise. Changes in the number of feed arteries perforating the muscle are thought to contribute to this altered hyperemic response during exercise. We tested the hypothesis that exercise training would ameliorate age-related differences in blood flow during exercise and feed artery structure in skeletal muscle. Young (6-7 mo old, n = 36) and old (24 mo old, n = 25) male Fischer 344 rats were divided into young sedentary (Sed), old Sed, young exercise-trained (ET), and old ET groups, where training consisted of 10-12 wk of treadmill exercise. In Sed and ET rats, blood flow to the red and white portions of the gastrocnemius muscle (Gast(Red) and Gast(White)) and the number and luminal cross-sectional area (CSA) of all feed arteries perforating the muscle were measured at rest and during exercise. In the old ET group, blood flow was greater to Gast(Red) (264 ± 13 and 195 ± 9 ml · min(-1) · 100 g(-1) in old ET and old Sed, respectively) and lower to Gast(White) (78 ± 5 and 120 ± 6 ml · min(-1) · 100 g(-1) in old ET and old Sed, respectively) than in the old Sed group. There was no difference in the number of feed arteries between the old ET and old Sed group, although the CSA of feed arteries from old ET rats was larger. In young ET rats, there was an increase in the number of feed arteries perforating the muscle. Exercise training mitigated old age-associated differences in blood flow during exercise within gastrocnemius muscle. However, training-induced adaptations in resistance artery morphology differed between young (increase in feed artery number) and old (increase in artery CSA) animals. The altered blood flow pattern induced by exercise training with old age would improve the local matching of O(2) delivery to consumption within the skeletal muscle.
Authors:
Bradley J Behnke; Michael W Ramsey; John N Stabley; James M Dominguez; Robert T Davis; Danielle J McCullough; Judy M Muller-Delp; Michael D Delp
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-10-04
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  113     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-05-29     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1699-708     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Age Factors
Aging*
Animals
Arterial Pressure
Arteries / anatomy & histology,  physiology
Blood Flow Velocity
Citrate (si)-Synthase / metabolism
Male
Muscle Contraction*
Muscle Fibers, Fast-Twitch / metabolism
Muscle Fibers, Slow-Twitch / metabolism
Muscle, Skeletal / blood supply*,  metabolism
Oxygen / blood
Oxygen Consumption
Physical Exertion*
Rats
Rats, Inbred F344
Regional Blood Flow
Sedentary Lifestyle
Vascular Resistance*
Grant Support
ID/Acronym/Agency:
AG-31317/AG/NIA NIH HHS; R01 HL-077224/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
EC 2.3.3.1/Citrate (si)-Synthase; S88TT14065/Oxygen
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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