| Effects of aging and exercise training on skeletal muscle blood flow and resistance artery morphology. | |
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MedLine Citation:
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PMID: 23042906 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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With old age there is reduced blood flow during exercise to the high-oxidative red skeletal muscle and elevated flow to the low-oxidative white muscle. Changes in the number of feed arteries perforating the muscle are thought to contribute to this altered hyperemic response during exercise. We tested the hypotheses that exercise training would ameliorate age-related differences in blood flow during exercise and feed artery structure in skeletal muscle. Young (6-7 mo old; n=36) and old (24 mo old; n=25) male Fischer 344 rats were divided into young sedentary (YSed), old sedentary (OSed), young exercise-trained (YET) or old exercise-trained (OET) groups, where training consisted of 10-12 weeks of treadmill exercise. In Sed and ET rats blood flow at rest and during exercise to the red and white portions of the gastrocnemius muscle (Gast(Red) and Gast(White), respectively), and the number and luminal cross-sectional area (CSA) of all feed arteries perforating the muscle were measured. In the old ET group, blood flow was greater to the Gast(Red) (OET: 264 ± 13, OSed: 195 ± 9 ml/min/100 g) and lower to the Gast(White) (OET: 78 ± 5, OSed: 120 ± 6 ml/min/100 g) during exercise versus OSed. There was no difference in the number of feed arteries in OET versus OSed, although feed arteries from OET rats had a larger CSA. In YET rats, there was an increase in the number of feed arteries perforating the muscle. Exercise training mitigated old age-associated differences in blood flow during exercise within gastrocnemius muscle. However, training-induced adaptations in resistance artery morphology differed between young (increase in feed artery number) and old (increase in artery CSA) animals. The altered blood flow pattern induced by ET with old age would improve the local matching of O(2) delivery-to-consumption within the skeletal muscle. |
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Authors:
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Bradley Jon Behnke; Michael W Ramsey; John N Stabley; James Michael Dominguez; Robert T Davis; Danielle Jillian McCullough; Judy M Muller-Delp; Micheal D Delp |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-4 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Florida. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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