| Effects of aging on current vocalization threshold in mice measured by a novel nociception assay. | |
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MedLine Citation:
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PMID: 16871071 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Age-related changes in nociception have been extensively studied in the past decades. However, it remains unclear whether in addition to the increased incidence of chronic illness, age-related changes in nociception contribute to increased prevalence of pain in the elderly. Although a great deal of evidence suggests that nociception thresholds increase with aging, other studies yield disparate results. The aim of this investigation was to longitudinally determine the effect of aging on nociception. METHODS: The authors developed a nociception assay for mice using electrical stimuli at 2,000, 250, and 5 Hz that reportedly stimulate Abeta, Adelta, and C sensory nerve fibers, respectively. A system was designed to automate a method that elicits and detects pain-avoiding behavior in mice. Using a Latin square design, the authors measured current vocalization thresholds serially over the course of mice's life span. RESULTS: For 2,000-Hz (Abeta), 250-Hz (Adelta), and 5-Hz (C) electrical stimuli, current vocalization thresholds first decreases and then increases with aging following a U-shaped pattern (P < 0.001). In addition, average current vocalization thresholds at youth and senescence are significantly higher than those at middle age for the 250-Hz (Adelta) and 5-Hz (C fiber) electrical stimulus (P < 0.05). CONCLUSIONS: Using a novel and noninjurious nociception assay, the authors showed that over the life span of mice, current vocalization threshold to electrical stimuli changes in a U-shaped pattern. The findings support the notion that age-related changes in nociception are curvilinear, and to properly study and treat pain, the age of subjects should be considered. |
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Authors:
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Julia C Finkel; Virginia G Besch; Adrienne Hergen; John Kakareka; Thomas Pohida; Jonathan M Melzer; Deloris Koziol; Robert Wesley; Zenaide M N Quezado |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural |
Journal Detail:
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Title: Anesthesiology Volume: 105 ISSN: 0003-3022 ISO Abbreviation: Anesthesiology Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-07-27 Completed Date: 2006-09-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: United States |
Other Details:
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Languages: eng Pagination: 360-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesia and Surgical Services, National Institutes of Health Clinical Center, National Institutes of Health, Bethesda, MD 20892-1512, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology* Animals Body Weight / physiology Data Interpretation, Statistical Electric Stimulation Female Mice Nerve Fibers, Myelinated / physiology Nerve Fibers, Unmyelinated / physiology Neurons, Afferent / physiology Pain / psychology Pain Measurement / methods* Pain Threshold / physiology* Reaction Time / physiology Vocalization, Animal / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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