| Effects of aging on basal fat oxidation in obese humans. | |
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MedLine Citation:
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PMID: 18640394 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Basal fat oxidation decreases with age. In obesity, it is not known whether this age-related process occurs independently of changes in body composition and insulin sensitivity. Therefore, body composition, resting energy expenditure, basal substrate oxidation, and maximal oxygen consumption (VO(2)max) were measured in 10 older (age, 60 +/- 4 years; mean +/- SEM) and 10 younger (age, 35 +/- 4 years) body mass index-matched, obese, normal glucose-tolerant individuals. Fasting blood samples were also collected. Older subjects had slightly elevated fat mass (32.2 +/- 7.1 vs 36.5 +/- 6.7 kg, P = .16); however, waist circumference was not different between groups (104.3 +/- 10.3 vs 102.1 +/- 12.6 cm, P = .65). Basal fat oxidation was 22% lower (1.42 +/- 0.14 vs 1.17 +/- 0.22 mg/kg fat-free mass per minute, P = .03) in older subjects. The VO(2)max was also decreased in older individuals (44.6 +/- 7.1 vs 38.3 +/- 6.0 mL/kg fat-free mass per minute, P = .03); but insulin sensitivity, lipemia, and leptinemia were not different between groups (P > .05). Fat oxidation was most related to age (r = -0.61, P = .003) and VO(2)max (r = 0.52, P = .01). These data suggest that aging per se is responsible for reduced basal fat oxidation and maximal oxidative capacity in older obese individuals, independent of changes in insulin resistance, body mass, and abdominal fat. This indicates that age, in addition to obesity, is an independent risk factor for weight gain and for the metabolic complications of elevated body fat. |
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Authors:
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Thomas P J Solomon; Christine M Marchetti; Raj K Krishnan; Frank Gonzalez; John P Kirwan |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 57 ISSN: 1532-8600 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-21 Completed Date: 2008-09-04 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: United States |
Other Details:
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Languages: eng Pagination: 1141-7 Citation Subset: IM |
Affiliation:
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Department of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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metabolism* Adult Aging / metabolism* Anthropometry Basal Metabolism Blood Glucose / metabolism Calorimetry, Indirect Cholesterol / blood Female Humans Insulin / blood Leptin / blood Male Middle Aged Obesity / blood, metabolism* Oxygen Consumption Triglycerides / blood |
| Grant Support | |
ID/Acronym/Agency:
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AG12834/AG/NIA NIH HHS; M01 RR000080-448000/RR/NCRR NIH HHS; M01 RR010732-030048/RR/NCRR NIH HHS; R01 AG012834-10/AG/NIA NIH HHS; RR00080/RR/NCRR NIH HHS; RR018390/RR/NCRR NIH HHS; RR10732/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Leptin; 0/Triglycerides; 11061-68-0/Insulin; 57-88-5/Cholesterol |
| Comments/Corrections | |
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