| Effects of age on tissues and regions of the cerebrum and cerebellum. | |
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MedLine Citation:
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PMID: 11445259 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Normal volunteers, aged 30 to 99 years, were studied with MRI. Age was related to estimated volumes of: gray matter, white matter, and CSF of the cerebrum and cerebellum; gray matter, white matter, white matter abnormality, and CSF within each cerebral lobe; and gray matter of eight subcortical structures. The results were: 1) Age-related losses in the hippocampus were significantly accelerated relative to gray matter losses elsewhere in the brain. 2) Among the cerebral lobes, the frontal lobes were disproportionately affected by cortical volume loss and increased white matter abnormality. 3) Loss of cerebral and cerebellar white matter occurred later than, but was ultimately greater than, loss of gray matter. It is estimated that between the ages of 30 and 90 volume loss averages 14% in the cerebral cortex, 35% in the hippocampus, and 26% in the cerebral white matter. Separate analyses were conducted in which genetic risk associated with the Apolipoprotein E epsilon4 allele was either overrepresented or underrepresented among elderly participants. Accelerated loss of hippocampal volume was observed with both analyses and thus does not appear to be due to the presence of at-risk subjects. MR signal alterations in the tissues of older individuals pose challenges to the validity of current methods of tissue segmentation, and should be considered in the interpretation of the results. |
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Authors:
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T L Jernigan; S L Archibald; C Fennema-Notestine; A C Gamst; J C Stout; J Bonner; J R Hesselink |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neurobiology of aging Volume: 22 ISSN: 0197-4580 ISO Abbreviation: Neurobiol. Aging Publication Date: 2001 Jul-Aug |
Date Detail:
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Created Date: 2001-07-10 Completed Date: 2001-08-30 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8100437 Medline TA: Neurobiol Aging Country: United States |
Other Details:
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Languages: eng Pagination: 581-94 Citation Subset: IM |
Affiliation:
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Veterans Affairs San Diego Healthcare System, San Diego, CA, USA. tjernigan@ucsd.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Aging / pathology* Apolipoprotein E4 Apolipoproteins E / genetics Cerebellum / pathology* Female Frontal Lobe / pathology* Hippocampus / pathology Humans Magnetic Resonance Imaging / standards* Male Middle Aged Nerve Fibers / pathology Reference Values |
| Grant Support | |
ID/Acronym/Agency:
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1P30MH49671/MH/NIMH NIH HHS; 1P50MH45294/MH/NIMH NIH HHS; 2P50AG05131/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein E4; 0/Apolipoproteins E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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