Document Detail

Effects of age on tissues and regions of the cerebrum and cerebellum.
MedLine Citation:
PMID:  11445259     Owner:  NLM     Status:  MEDLINE    
Normal volunteers, aged 30 to 99 years, were studied with MRI. Age was related to estimated volumes of: gray matter, white matter, and CSF of the cerebrum and cerebellum; gray matter, white matter, white matter abnormality, and CSF within each cerebral lobe; and gray matter of eight subcortical structures. The results were: 1) Age-related losses in the hippocampus were significantly accelerated relative to gray matter losses elsewhere in the brain. 2) Among the cerebral lobes, the frontal lobes were disproportionately affected by cortical volume loss and increased white matter abnormality. 3) Loss of cerebral and cerebellar white matter occurred later than, but was ultimately greater than, loss of gray matter. It is estimated that between the ages of 30 and 90 volume loss averages 14% in the cerebral cortex, 35% in the hippocampus, and 26% in the cerebral white matter. Separate analyses were conducted in which genetic risk associated with the Apolipoprotein E epsilon4 allele was either overrepresented or underrepresented among elderly participants. Accelerated loss of hippocampal volume was observed with both analyses and thus does not appear to be due to the presence of at-risk subjects. MR signal alterations in the tissues of older individuals pose challenges to the validity of current methods of tissue segmentation, and should be considered in the interpretation of the results.
T L Jernigan; S L Archibald; C Fennema-Notestine; A C Gamst; J C Stout; J Bonner; J R Hesselink
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurobiology of aging     Volume:  22     ISSN:  0197-4580     ISO Abbreviation:  Neurobiol. Aging     Publication Date:    2001 Jul-Aug
Date Detail:
Created Date:  2001-07-10     Completed Date:  2001-08-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8100437     Medline TA:  Neurobiol Aging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  581-94     Citation Subset:  IM    
Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.
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MeSH Terms
Aged, 80 and over
Aging / pathology*
Apolipoprotein E4
Apolipoproteins E / genetics
Cerebellum / pathology*
Frontal Lobe / pathology*
Hippocampus / pathology
Magnetic Resonance Imaging / standards*
Middle Aged
Nerve Fibers / pathology
Reference Values
Grant Support
Reg. No./Substance:
0/Apolipoprotein E4; 0/Apolipoproteins E

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