| Effects of age, reproductive status and ambient temperature on skin temperature regulation in the female rat. | |
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MedLine Citation:
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PMID: 7752956 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the present study, we evaluated a large population of aged Long-Evans female rats for the occurrence of spontaneous tail skin temperature (TST) surges. Young (5-7 months) normally cycling (NC) rats and aged (19-29 months), repeated pseudopregnant (PP) and constant estrous (CE) rats were placed in an environmentally controlled room with ambient temperatures of 24-25 degrees C or 29-30 degrees C and TST was monitored at 5 min intervals for 2 h. In young NC and aged PP rats, the incidence of TST surges (flushes) was 8-17% at low and 28-33% at high ambient temperature. Old CE rats exhibited a flushing incidence of 21% and 74% at ambient temperatures of 24-25 degrees C and 29-30 degrees C, respectively. The observed flushing episodes did not differ in their duration or amplitude among the three groups of rats. However, at both low and high ambient temperature, the frequency of flushes were significantly higher in old CE rats. Collectively, these data indicate that reproductive status, rather than age, is the important determinant of TST stability in the female rat. Further, elevated estrogen associated with the CE state may compromise, while elevated progesterone associated with the PP state has a protective effect on the stability of TST in the female rat. |
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Authors:
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J W Simpkins |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Maturitas Volume: 21 ISSN: 0378-5122 ISO Abbreviation: Maturitas Publication Date: 1995 Feb |
Date Detail:
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Created Date: 1995-06-20 Completed Date: 1995-06-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7807333 Medline TA: Maturitas Country: IRELAND |
Other Details:
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Languages: eng Pagination: 97-102 Citation Subset: IM |
Affiliation:
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Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville 32610, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology* Animals Body Temperature Regulation* Estrus / physiology* Female Flushing / physiopathology Pseudopregnancy / physiopathology* Rats Skin Temperature* |
| Grant Support | |
ID/Acronym/Agency:
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AG10485/AG/NIA NIH HHS; HD18133/HD/NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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