Document Detail

Effects of age of introduction of complementary foods on iron status of breast-fed infants in Honduras.
MedLine Citation:
PMID:  9583845     Owner:  NLM     Status:  MEDLINE    
To evaluate the effect of introducing complementary foods before 6 mo of age, we randomly assigned 164 infants who had been exclusively breast-fed for 4 mo to continue being exclusively breast-fed until 6 mo (EBF group) or to receive iron-fortified foods in addition to breast milk from 4 to 6 mo (BF+SF group). At 6 mo, the BF+SF group had higher mean iron intake (4 mg/d compared with 0.2 mg/d in EBF infants) and higher hemoglobin, hematocrit, and ferritin values than the EBF group (P < 0.05). The percentage with low hemoglobin (< 103 g/L) did not differ significantly between groups, but fewer infants in the BF+SF group had a low hematocrit (< 0.33; 21.4% compared with 32.0%, respectively; P < 0.05). The percentage of infants with ferritin concentrations < 12 microg/L at 6 mo was lower than the percentage with low hemoglobin or hematocrit, raising questions about the validity of the cutoffs at this age. Infants at greatest risk for anemia and low ferritin were those with birth weights < 2500 g; no infant with a birth weight > 3000 g had a low ferritin value at 6 mo. We conclude that the risk of iron deficiency is low among infants with birth weights > 3000 g who are exclusively breast-fed for 6 mo. Iron drops are recommended for low-birth-weight infants; for breast-fed infants with birth weights between 2500 and 3000 g, further research is needed to determine whether iron drops are more effective than complementary foods for preventing iron deficiency before 6 mo.
K G Dewey; R J Cohen; L L Rivera; K H Brown
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  67     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-05-26     Completed Date:  1998-05-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  878-84     Citation Subset:  AIM; IM    
Department of Nutrition, University of California, Davis 95616-8669, USA.
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MeSH Terms
Age Factors*
Birth Weight
Bottle Feeding
Breast Feeding / ethnology*
C-Reactive Protein / drug effects,  metabolism
Energy Intake
Ferritins / blood*,  drug effects
Food, Fortified
Hemoglobins / drug effects,  metabolism
Infant Food*
Iron / administration & dosage
Multivariate Analysis
Regression Analysis
Reg. No./Substance:
0/Hemoglobins; 7439-89-6/Iron; 9007-41-4/C-Reactive Protein; 9007-73-2/Ferritins
Comment In:
Am J Clin Nutr. 1998 May;67(5):815-6   [PMID:  9583834 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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