| Effects of age and gender on the pharmacodynamics of omapatrilat in healthy volunteers. | |
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MedLine Citation:
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PMID: 11413936 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Omapatrilat is the most clinically advanced member of a new class of cardiovascular drugs, vasopeptidase inhibitors. Omapatrilat is a single molecule that simultaneously inhibits neutral endopeptidase and angiotensin-converting enzyme, thus preserving vasodilator peptides and inhibiting production of the vasoconstrictor angiotensin II. In healthy male volunteers, omapatrilat decreased blood pressure while being generally well tolerated, with no serious adverse events. This study was undertaken to determine the effect of age and gender on the pharmacodynamics of omapatrilat. Healthy male or female volunteers between the ages of 18 and 80 were given a single oral dose of omapatrilat 40 mg. Neither age nor gender affected the vasopeptidase inhibition by omapatrilat. There were no differences between subject groups in the effect of omapatrilat on supine systolic, diastolic, or mean arterial blood pressure. Based on this study of healthy subjects, it can be concluded that it is not necessary to adjust the initial dose of omapatrilat for the treatment of hypertension based solely on age or gender. |
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Authors:
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W Liao; O Vesterqvist; J Manning; J L Hammett; I M Ferreira; A Meier; K D Davis; H W Hutman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of geriatric cardiology Volume: 10 ISSN: 1076-7460 ISO Abbreviation: Am J Geriatr Cardiol Publication Date: 2001 Jan-Feb |
Date Detail:
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Created Date: 2001-06-20 Completed Date: 2001-07-12 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9215283 Medline TA: Am J Geriatr Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 50-4 Citation Subset: IM |
Affiliation:
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Bristol-Myers Squibb Pharmaceutical Research Institute, P.O. Box 4000, Princeton, NJ 08543-4000, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Aging / blood* Cardiovascular Agents / pharmacokinetics* Female Humans Male Metabolic Clearance Rate Middle Aged Pyridines / pharmacokinetics* Reference Values Sex Factors Thiazepines / pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
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0/Cardiovascular Agents; 0/Pyridines; 0/Thiazepines; 0/omapatrilat |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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