Document Detail

Effects of age and fitness on tolerance to lower body negative pressure.
MedLine Citation:
PMID:  15983183     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The purpose of this investigation was to determine the effects of age and fitness on tolerance to maximal lower body negative pressure (LBNP). METHODS: Ten older fit (OF) [73.9 +/- 2 years; 39.0 +/- 2 (age and estimated VO(2)peak, respectively)], 10 older unfit (OU) (70.9 +/- 1 years; 27.1 +/- 2, 10 young fit (YF) (22.6 +/- 0.5 years; 57.1 +/- 2, and 10 young unfit (YU) (23.1 +/- 1 years; 41.1 +/- 2 participants underwent graded LBNP of -10 mmHg every 4 minutes to either presyncope or -100 mmHg. RESULTS: Compared to the other groups, YF had an earlier increase in heart rate (-40 mmHg vs the last stage; YF vs OF, OU, and YU, respectively) and decline in stroke volume (-20 mmHg vs -40 mmHg; YF vs OF, OU, and YU, respectively). OU had a higher resting mean arterial pressure; this difference was maintained until the last stage. OF had an earlier decline in total peripheral conductance than the other groups (-20 mmHg vs -40 mmHg). Tolerance to maximal LBNP did not differ among the groups. CONCLUSIONS: Despite differences in the responses to submaximal LBNP, neither age nor cardiovascular fitness affect tolerance to maximal LBNP.
Juliane P Hernandez; Amruta Karandikar; Warren D Franke
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The journals of gerontology. Series A, Biological sciences and medical sciences     Volume:  60     ISSN:  1079-5006     ISO Abbreviation:  J. Gerontol. A Biol. Sci. Med. Sci.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-28     Completed Date:  2005-08-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9502837     Medline TA:  J Gerontol A Biol Sci Med Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  782-6     Citation Subset:  AIM; IM    
Department of Health and Human Performance, Iowa State University, Ames, Iowa, USA.
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MeSH Terms
Age Factors
Heart Rate / physiology
Hemodynamics / physiology
Lower Body Negative Pressure*
Middle Aged
Physical Fitness / physiology*
Stroke Volume / physiology
Syncope / etiology

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