Document Detail


Effects of age on elastic moduli of human lungs.
MedLine Citation:
PMID:  10904048     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The model of the lung as an elastic continuum undergoing small distortions from a uniformly inflated state has been used to describe many lung deformation problems. Lung stress-strain material properties needed for this model are described by two elastic moduli: the bulk modulus, which describes a uniform inflation, and the shear modulus, which describes an isovolume deformation. In this study we measured the bulk modulus and shear modulus of human lungs obtained at autopsy at several fixed transpulmonary pressures (Ptp). The bulk modulus was obtained from small pressure-volume perturbations on different points of the deflation pressure-volume curve. The shear modulus was obtained from indentation tests on the lung surface. The results indicated that, at a constant Ptp, both bulk and shear moduli increased with age, and the increase was greater at higher Ptp values. The micromechanical basis for these changes remains to be elucidated.
Authors:
S J Lai-Fook; R E Hyatt
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  89     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-08-21     Completed Date:  2000-08-21     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  163-8     Citation Subset:  IM    
Affiliation:
Center for Biomedical Engineering, University of Kentucky, Lexington, Kentucky 40506, USA. laifook@pop.uky.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aging / physiology*
Cadaver
Child
Elasticity
Female
Humans
Linear Models
Lung / physiology*
Lung Compliance / physiology
Lung Volume Measurements
Male
Middle Aged
Poisson Distribution
Pressure
Respiratory Mechanics / physiology
Surface Properties
Grant Support
ID/Acronym/Agency:
HL-18354/HL/NHLBI NIH HHS; HL-21584/HL/NHLBI NIH HHS; HL-40362/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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