| Effects of age and diet on small intestinal structure and function in gnotobiotic piglets. | |
| | |
MedLine Citation:
|
PMID: 2512599 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effects of age and dietary change on the structure and function of piglet small intestine were investigated in gnotobiotic pigs. The small intestinal mucosa was damaged when gnotobiotic pigs were weaned on to a pelleted meal diet; villus height, crypt cell production rate, and activities of brush border enzymes were reduced. Small intestinal damage was associated with reduced weight gain over a three week period; diarrhoea was not observed. The continuous consumption of meal appeared to perpetuate the intestinal damage for three weeks, although evidence of intestinal repair, as indicated by an increased crypt cell production rate, was present three weeks after weaning. Antibodies to soya antigen were detected in serum after weaning and the intestinal damage could have been caused by antibody-mediated immune reactions to soya proteins. Villi of milk fed gnotobiotic pigs shortened significantly with age. |
| | |
Authors:
|
G A Hall; T F Byrne |
Related Documents
:
|
7138989 - Effect of body weight on postnatal development of the proximal small intestine of the r... 9153299 - Grapefruit juice increases felodipine oral availability in humans by decreasing intesti... 2841519 - The effects of diet on the residual small intestine following massive resection. 10188819 - Influence of fermentable fiber on small intestinal dimensions and transport of glucose ... 1645209 - Starch and dietary fibre: their physiological and epidemiological interrelationships. 4063319 - Effect of kidney bean (phaseolus vulgaris) toxin on tissue weight and composition and s... 8049189 - Factor vii coagulant activity and cholesterol changes in premenopausal women consuming ... 17152919 - Lymphatic recovery of exogenous oleic acid in rats on long chain or specific structured... 2235839 - Conditions necessary for a response by the commercial laying hen to supplemental cholin... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Research in veterinary science Volume: 47 ISSN: 0034-5288 ISO Abbreviation: Res. Vet. Sci. Publication Date: 1989 Nov |
Date Detail:
|
Created Date: 1990-01-18 Completed Date: 1990-01-18 Revised Date: 2009-09-29 |
Medline Journal Info:
|
Nlm Unique ID: 0401300 Medline TA: Res Vet Sci Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 387-92 Citation Subset: IM |
Affiliation:
|
AFRC Institute for Animal Health, Compton Laboratory, Newbury, Berkshire. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aging
/
physiology* Animal Feed Animals Diet* Germ-Free Life Intestinal Mucosa / anatomy & histology, physiology Intestine, Small / anatomy & histology*, enzymology, physiology Microscopy, Electron Microvilli / ultrastructure Random Allocation Sucrase / metabolism Swine / anatomy & histology*, growth & development, physiology Weaning Weight Gain beta-Galactosidase / metabolism |
| Grant Support | |
ID/Acronym/Agency:
|
//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
|
EC 3.2.1.23/beta-Galactosidase; EC 3.2.1.48/Sucrase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of misoprostol and omeprazole on basal gastric pH and free acid content in horses.
Next Document: Toxicity and clearance of a combination of liposome-encapsulated ganciclovir and trifluridine.