Document Detail

Effects of age on circadian blood pressure and heart rate rhythms in patients with primary hypertension.
MedLine Citation:
PMID:  8013049     Owner:  NLM     Status:  MEDLINE    
To evaluate whether circadian rhythms in blood pressure and heart rate are influenced by age, we analyzed 24-h ambulatory blood pressure and heart rate recordings from 31 patients with primary hypertension. Data were collected during hospitalization, after a drug-free run-in period. Set times were administered for lights-on, meals, and lights-off. Daytime napping was prohibited. The patients were divided into sex-matched groups of young (group I: 25-45 years, n = 9), middle-aged (group II: 47-57 years, n = 11), and old (group III: 57-74 years, n = 11) subjects. Hourly data were analysed by fitting a two-component cosine function (24- and 12-h periods). Amplitudes of the circadian rhythms in systolic blood pressure and heart rate were significantly reduced with age. This finding could be partly attributed to the recording of higher nocturnal values in older patients. Elderly hypertensives also evidenced a significantly greater ultradian component (12-h period) in the systolic blood pressure rhythm than did young patients, with the secondary afternoon decline in blood pressure being more pronounced in groups II and III. The 24-h acrophase of heart rate was found to occur approximately 1.6 h earlier than that of systolic blood pressure in the young group (p < 0.01). This phase advance of heart rate compared with systolic blood pressure was reduced to 1 h in group II (p < 0.05) and was not evident in group III (p > 0.1). These results indicate that circadian blood pressure and heart rate profiles of primary hypertensives change with age. Since measures were obtained in a typical clinical setting, these findings have implications for the diagnosis and treatment of hypertension in the elderly. The marked afternoon decline in blood pressure for the elderly patients may also render conventional cosinor analysis inappropriate for accurate description of the circadian rhythms of geriatric hypertensives.
G Atkinson; K Witte; G Nold; U Sasse; B Lemmer
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Chronobiology international     Volume:  11     ISSN:  0742-0528     ISO Abbreviation:  Chronobiol. Int.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-07-22     Completed Date:  1994-07-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8501362     Medline TA:  Chronobiol Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  35-44     Citation Subset:  IM    
School of Human Sciences, Liverpool John Moores University, England.
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MeSH Terms
Age Factors
Aging / physiology*
Blood Pressure*
Circadian Rhythm*
Heart Rate*
Hypertension / physiopathology*
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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