Document Detail

Effects of age at first pregnancy and breast-feeding on the development of postmenopausal osteoporosis.
MedLine Citation:
PMID:  20613669     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Although pregnancy and breast-feeding require adequate calcium mobilization, it is not known if these affect the acquisition of a healthy peak bone mass (PBM) and, hence, postmenopausal osteoporosis (OPS). The objective of this study was to analyze previous pregnancies and/or breast-feeding and their association with OPS.
METHODS: After obtaining institutional review board approval, postmenopausal women (>49 y) presenting for a dual-energy x-ray absorptiometry bone density scan were invited to participate. Risk factors for OPS, including previous fractures, pregnancy information, and dual-energy x-ray absorptiometry results, were collected. OPS was defined as a T score of -2.5 or lower.
RESULTS: Data were obtained from 619 women. Of these, 49.8% were smokers, 27.2% used a bisphosphonate, 64.1% used hormone therapy, and 5.5% had used steroids. Based on PBM, ages at first pregnancy were dichotomized to younger than 27 years and 27 years or older. Women with a history of breast-feeding had a lower prevalence of OPS (7.6%) versus women who had never breast-fed (18.7%; P < 0.001). Women with a first pregnancy when they were 27 years or older and a history of breast-feeding had the lowest prevalence of OPS (4.6%) versus women with a first pregnancy when they were younger than 27 years and no history of breast-feeding (16.3%; P = 0.001).
CONCLUSIONS: Breast-feeding seems to significantly decrease the incidence of postmenopausal OPS. Women whose first pregnancy occurs after PBM (≥27 y of age) and who have a history of breast-feeding had the lowest prevalence of OPS. Thus, an association between OPS and both breast-feeding and age of pregnancy seems to be present.
Peter F Schnatz; Kathaleen G Barker; Kimberly A Marakovits; David M O'Sullivan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Menopause (New York, N.Y.)     Volume:  17     ISSN:  1530-0374     ISO Abbreviation:  Menopause     Publication Date:    2010 Nov-Dec
Date Detail:
Created Date:  2010-11-11     Completed Date:  2011-03-02     Revised Date:  2011-08-11    
Medline Journal Info:
Nlm Unique ID:  9433353     Medline TA:  Menopause     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1161-6     Citation Subset:  IM    
Department of Obstetrics and Gynecology, The Reading Hospital and Medical Center, Reading, PA 19612-6052, USA.
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MeSH Terms
Absorptiometry, Photon
Age Factors
Breast Feeding*
Cross-Sectional Studies
Interviews as Topic
Logistic Models
Maternal Age*
Middle Aged
Osteoporosis, Postmenopausal / epidemiology*,  radiography
Reproductive History
Risk Factors
Comment In:
Menopause. 2011 May;18(5):590-1; author response 591   [PMID:  21487314 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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