| Effects of age at first pregnancy and breast-feeding on the development of postmenopausal osteoporosis. | |
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MedLine Citation:
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PMID: 20613669 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Although pregnancy and breast-feeding require adequate calcium mobilization, it is not known if these affect the acquisition of a healthy peak bone mass (PBM) and, hence, postmenopausal osteoporosis (OPS). The objective of this study was to analyze previous pregnancies and/or breast-feeding and their association with OPS. METHODS: After obtaining institutional review board approval, postmenopausal women (>49 y) presenting for a dual-energy x-ray absorptiometry bone density scan were invited to participate. Risk factors for OPS, including previous fractures, pregnancy information, and dual-energy x-ray absorptiometry results, were collected. OPS was defined as a T score of -2.5 or lower. RESULTS: Data were obtained from 619 women. Of these, 49.8% were smokers, 27.2% used a bisphosphonate, 64.1% used hormone therapy, and 5.5% had used steroids. Based on PBM, ages at first pregnancy were dichotomized to younger than 27 years and 27 years or older. Women with a history of breast-feeding had a lower prevalence of OPS (7.6%) versus women who had never breast-fed (18.7%; P < 0.001). Women with a first pregnancy when they were 27 years or older and a history of breast-feeding had the lowest prevalence of OPS (4.6%) versus women with a first pregnancy when they were younger than 27 years and no history of breast-feeding (16.3%; P = 0.001). CONCLUSIONS: Breast-feeding seems to significantly decrease the incidence of postmenopausal OPS. Women whose first pregnancy occurs after PBM (≥27 y of age) and who have a history of breast-feeding had the lowest prevalence of OPS. Thus, an association between OPS and both breast-feeding and age of pregnancy seems to be present. |
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Authors:
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Peter F Schnatz; Kathaleen G Barker; Kimberly A Marakovits; David M O'Sullivan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Menopause (New York, N.Y.) Volume: 17 ISSN: 1530-0374 ISO Abbreviation: Menopause Publication Date: 2010 Nov-Dec |
Date Detail:
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Created Date: 2010-11-11 Completed Date: 2011-03-02 Revised Date: 2011-08-11 |
Medline Journal Info:
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Nlm Unique ID: 9433353 Medline TA: Menopause Country: United States |
Other Details:
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Languages: eng Pagination: 1161-6 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, The Reading Hospital and Medical Center, Reading, PA 19612-6052, USA. schnatzp@readinghospital.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Age Factors Aged Breast Feeding* Cross-Sectional Studies Female Humans Interviews as Topic Logistic Models Maternal Age* Middle Aged Osteoporosis, Postmenopausal / epidemiology*, radiography Postmenopause Pregnancy* Prevalence Reproductive History Risk Factors |
| Comments/Corrections | |
Comment In:
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Menopause. 2011 May;18(5):590-1; author response 591
[PMID:
21487314
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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