Document Detail

Effects of aflatoxin B1 and fumonisin B1 on body weight, antibody titres and histology of broiler chicks.
MedLine Citation:
PMID:  16787861     Owner:  NLM     Status:  MEDLINE    
1. Our objective was to evaluate the toxic effects of aflatoxin B1 (AFB1) and fumonisin B1 (FB1), administered singly or in combination to broilers. 2. Feeds were prepared with concentrations equal to 0, 50 and 200 microg AFB1/kg, and/or 0, 50 and 200 mg FB1/kg, and offered to broiler chicks from 8 to 41 d of age. The experimental design was totally randomised, in a 3 x 3 factorial arrangement with 9 treatments and 12 birds per treatment. Animals were vaccinated against Newcastle disease on d 14 of life and killed at 41 d. 3. Compared with controls, all mycotoxin-treated groups at 41 d had lower body weight and weight gain, and higher relative heart weight. The relative weight of the liver increased only in birds fed diets containing 200 mg FB1, singly or in combination with AFB1. 4. At 35 d, all groups receiving mycotoxin-treated rations had reduced geometrical mean antibody titres, with birds from groups fed combinations of AFB1 and FB1/kg having even lower values, when compared to the other groups. 5. Histological changes were observed only in liver from birds fed mycotoxin-contaminated rations, and in kidneys of birds fed the diet containing 200 microg AFB1 and 200 mg FB1/kg. Main alterations included vacuolar degeneration and cell proliferation of bile ducts in the liver, and hydropic degeneration in renal tubules in the kidneys. 6. We concluded that AFB1 and FB1 in combination have primarily additive effects on body weight, liver structure and immunological response of broilers at the concentrations used.
E N C Tessari; C A F Oliveira; A L S P Cardoso; D R Ledoux; G E Rottinghaus
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British poultry science     Volume:  47     ISSN:  0007-1668     ISO Abbreviation:  Br. Poult. Sci.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-21     Completed Date:  2006-08-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  15740290R     Medline TA:  Br Poult Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  357-64     Citation Subset:  IM    
Centro Avançado de Pesquisa Tecnológica do Agronegócio Avícola, Instituto Biológico, Descalvado, SP, Brazil.
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MeSH Terms
Aflatoxin B1 / toxicity*
Animal Feed
Antibodies, Viral / blood
Body Weight / drug effects*
Fumonisins / toxicity*
Kidney / pathology
Liver / pathology
Mycotoxicosis / immunology*
Newcastle Disease / prevention & control
Poultry Diseases / immunology*
Random Allocation
Viral Vaccines / immunology
Reg. No./Substance:
0/Antibodies, Viral; 0/Fumonisins; 0/Viral Vaccines; 1162-65-8/Aflatoxin B1; 116355-83-0/fumonisin B1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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