Document Detail


Effects of afferent and efferent celiac nerves on acute gastric lesions: due to changes in blood flow?
MedLine Citation:
PMID:  8338279     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Since ablation of afferent nerves prior to stress results in increased severity of acute gastric mucosal lesions, afferent nerves are thought to mediate protective mechanisms in the stomach. These mechanisms are known to include vasodilation of gastric mucosal vessels; vasodilation is thought to allow the gastric mucosa to respond to injurious substances. However, it is not known whether other aspects of mucosal health, independent of those caused by increased blood blow, are affected by afferent blockade. This study compared gastric blood flow and acute gastric mucosal lesions during stress in rats with either chemical sympathectomy or afferent blockade. The purpose of the study was to compare the lesion index and blood flow in each treatment group. The lesion index was highest in rats with afferent blockade and lowest after sympathectomy. Gastric blood flow was partially preserved after sympathectomy, but was not greatly increased, suggesting that some of the effects observed after afferent blockade are unrelated to changes in blood flow.
Authors:
K Anan; P E Donahue; M D Doyle; L M Nyhus
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American surgeon     Volume:  59     ISSN:  0003-1348     ISO Abbreviation:  Am Surg     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-08-26     Completed Date:  1993-08-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370522     Medline TA:  Am Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  500-4     Citation Subset:  IM    
Affiliation:
Division of General Surgery, Cook County Hospital, Chicago, Illinois 60612.
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MeSH Terms
Descriptor/Qualifier:
Animals
Autonomic Nerve Block
Capsaicin / pharmacology
Ganglia, Sympathetic / drug effects,  physiology*
Gastric Mucosa / blood supply,  pathology
Gastrointestinal Hemorrhage / etiology,  pathology,  physiopathology
Neurons, Afferent / drug effects,  physiology*
Neurons, Efferent / drug effects,  physiology*
Oxidopamine / pharmacology
Rats
Rats, Sprague-Dawley
Regional Blood Flow / physiology
Stomach / blood supply*,  pathology
Stomach Diseases / etiology*,  pathology,  physiopathology
Stress, Physiological / physiopathology
Sympathectomy, Chemical
Chemical
Reg. No./Substance:
1199-18-4/Oxidopamine; 404-86-4/Capsaicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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