Document Detail

Effects of afferent and efferent celiac nerves on acute gastric lesions: due to changes in blood flow?
MedLine Citation:
PMID:  8338279     Owner:  NLM     Status:  MEDLINE    
Since ablation of afferent nerves prior to stress results in increased severity of acute gastric mucosal lesions, afferent nerves are thought to mediate protective mechanisms in the stomach. These mechanisms are known to include vasodilation of gastric mucosal vessels; vasodilation is thought to allow the gastric mucosa to respond to injurious substances. However, it is not known whether other aspects of mucosal health, independent of those caused by increased blood blow, are affected by afferent blockade. This study compared gastric blood flow and acute gastric mucosal lesions during stress in rats with either chemical sympathectomy or afferent blockade. The purpose of the study was to compare the lesion index and blood flow in each treatment group. The lesion index was highest in rats with afferent blockade and lowest after sympathectomy. Gastric blood flow was partially preserved after sympathectomy, but was not greatly increased, suggesting that some of the effects observed after afferent blockade are unrelated to changes in blood flow.
K Anan; P E Donahue; M D Doyle; L M Nyhus
Related Documents :
1950779 - Vagal afferent innervation and regulation of gastric function.
8228079 - Mucosal blood flow in erosive duodenitis.
9274469 - Blood groups lewis(b) and abh expression in gastric mucosa: lack of inter-relation with...
7245049 - Contrasting effects of vasodilators on oxygen tension and membrane potential of canine ...
6745599 - Endoscopical determination of gastric mucosal blood flow by the crossed thermocouple me...
15769309 - Therapeutic effect of cisapride on gastric injury following hemorrhagic shock resuscita...
2386619 - Prevention of transfusion-associated hiv transmission in kinshasa, zaire: hiv screening...
1903409 - The effect of oral nitroglycerin on portal blood velocity as measured by ultrasonic dop...
1662199 - Quantification of concentration changes in neonatal human cerebral oxidized cytochrome ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American surgeon     Volume:  59     ISSN:  0003-1348     ISO Abbreviation:  Am Surg     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-08-26     Completed Date:  1993-08-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370522     Medline TA:  Am Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  500-4     Citation Subset:  IM    
Division of General Surgery, Cook County Hospital, Chicago, Illinois 60612.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Autonomic Nerve Block
Capsaicin / pharmacology
Ganglia, Sympathetic / drug effects,  physiology*
Gastric Mucosa / blood supply,  pathology
Gastrointestinal Hemorrhage / etiology,  pathology,  physiopathology
Neurons, Afferent / drug effects,  physiology*
Neurons, Efferent / drug effects,  physiology*
Oxidopamine / pharmacology
Rats, Sprague-Dawley
Regional Blood Flow / physiology
Stomach / blood supply*,  pathology
Stomach Diseases / etiology*,  pathology,  physiopathology
Stress, Physiological / physiopathology
Sympathectomy, Chemical
Reg. No./Substance:
1199-18-4/Oxidopamine; 404-86-4/Capsaicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Hospitalization and injury influence on the prosecution of drunk drivers.
Next Document:  Risk of pulmonary emboli in patients with pelvic fractures.