Document Detail

Effects of aerosolized albuterol on physiologic responses to exercise in standardbreds.
MedLine Citation:
PMID:  11703029     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the effects of an aerosolized beta2-adrenoreceptor agonist, albuterol, on performance during a standardized incremental exercise test in clinically normal horses. ANIMALS: 8 Standardbred pacing mares. PROCEDURE: Clinically normal horses, as judged by use of physical examination, hematologic findings, serum biochemical analysis, and airway endoscopy, were randomly assigned to 2 groups and were given 900 microg of albuterol via a metered-dose inhaler 30 minutes before beginning a standardized incremental exercise test in a crossover design with a 7-day minimum washout. Further examination included measurement of baseline lung mechanics, response to histamine bronchoprovocation, and bronchoalveolar lavage. RESULTS: No significant differences (albuterol vs placebo) were seen for any incremental exercise test variables (ie, maximum oxygen consumption, maximum carbon dioxide consumption, respiratory quotient, treadmill speed at heart rate of 200 beats/min, or number of steps completed during an incremental exercise protocol). Mast cell percentage was significantly (r = -0.84) associated with the concentration of aerosolized histamine that evoked a 100% increase in total respiratory system resistance. No other direct correlations between bronchoalveolar lavage fluid cell types and any indices of exercise capacity or airway reactivity were found. CONCLUSIONS AND CLINICAL RELEVANCE: Although no horse had exercise intolerance, 4 horses had airway hyperreactivity with bronchoalveolar lavage fluid mastocytosis; these horses may have been subclinically affected with inflammatory airway disease. In our study, albuterol did not enhance performance in 8 clinically normal racing-fit Standardbreds.
M R Mazan; A M Hoffman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of veterinary research     Volume:  62     ISSN:  0002-9645     ISO Abbreviation:  Am. J. Vet. Res.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-12     Completed Date:  2002-04-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375011     Medline TA:  Am J Vet Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1812-7     Citation Subset:  IM    
Department of Clinical Sciences, School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA.
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MeSH Terms
Adrenergic beta-Agonists / administration & dosage,  pharmacology*
Albuterol / administration & dosage,  pharmacology*
Bronchoalveolar Lavage Fluid / cytology
Cross-Over Studies
Heart Rate / drug effects,  physiology
Histamine / pharmacology
Horses / physiology*
Mast Cells / drug effects,  physiology
Oxygen Consumption / drug effects,  physiology
Physical Conditioning, Animal / physiology*
Random Allocation
Respiratory Function Tests / veterinary
Statistics, Nonparametric
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Aerosols; 18559-94-9/Albuterol; 51-45-6/Histamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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