| Effects of aerobic and resistance training on hemoglobin A1c levels in patients with type 2 diabetes: a randomized controlled trial. | |
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MedLine Citation:
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PMID: 21098771 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Exercise guidelines for individuals with diabetes include both aerobic and resistance training although few studies have directly examined this exercise combination. OBJECTIVE: To examine the benefits of aerobic training alone, resistance training alone, and a combination of both on hemoglobin A(1c) (HbA(1c)) in individuals with type 2 diabetes. DESIGN, SETTING, AND PARTICIPANTS: A randomized controlled trial in which 262 sedentary men and women in Louisiana with type 2 diabetes and HbA(1c) levels of 6.5% or higher were enrolled in the 9-month exercise program between April 2007 and August 2009. INTERVENTION: Forty-one participants were assigned to the nonexercise control group, 73 to resistance training 3 days a week, 72 to aerobic exercise in which they expended 12 kcal/kg per week; and 76 to combined aerobic and resistance training in which they expended 10 kcal/kg per week and engaged in resistance training twice a week. Main Outcome Change in HbA(1c) level. Secondary outcomes included measures of anthropometry and fitness. RESULTS: The study included 63.0% women and 47.3% nonwhite participants who were a mean (SD) age of 55.8 years (8.7 years) with a baseline HbA(1c) level of 7.7% (1.0%). Compared with the control group, the absolute mean change in HbA(1c) in the combination training exercise group was -0.34% (95% confidence interval [CI], -0.64% to -0.03%; P = .03). The mean changes in HbA(1c) were not statistically significant in either the resistance training (-0.16%; 95% CI, -0.46% to 0.15%; P = .32) or the aerobic (-0.24%; 95% CI, -0.55% to 0.07%; P = .14) groups compared with the control group. Only the combination exercise group improved maximum oxygen consumption (mean, 1.0 mL/kg per min; 95% CI, 0.5-1.5, P < .05) compared with the control group. All exercise groups reduced waist circumference from -1.9 to -2.8 cm compared with the control group. The resistance training group lost a mean of -1.4 kg fat mass (95% CI, -2.0 to -0.7 kg; P < .05) and combination training group lost a mean of -1.7 (-2.3 to -1.1 kg; P < .05) compared with the control group. CONCLUSIONS: Among patients with type 2 diabetes mellitus, a combination of aerobic and resistance training compared with the nonexercise control group improved HbA(1c) levels. This was not achieved by aerobic or resistance training alone. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00458133. |
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Authors:
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Timothy S Church; Steven N Blair; Shannon Cocreham; Neil Johannsen; William Johnson; Kimberly Kramer; Catherine R Mikus; Valerie Myers; Melissa Nauta; Ruben Q Rodarte; Lauren Sparks; Angela Thompson; Conrad P Earnest |
Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: JAMA : the journal of the American Medical Association Volume: 304 ISSN: 1538-3598 ISO Abbreviation: JAMA Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2010-11-29 Revised Date: 2012-04-26 |
Medline Journal Info:
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Nlm Unique ID: 7501160 Medline TA: JAMA Country: United States |
Other Details:
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Languages: eng Pagination: 2253-62 Citation Subset: AIM; IM |
Affiliation:
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Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, LA 70808-4124, USA. tim.church@pbrc.edu |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00458133 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anthropometry Diabetes Mellitus, Type 2 / blood*, therapy* Exercise Therapy* Female Hemoglobin A, Glycosylated / analysis* Humans Male Middle Aged Physical Fitness Resistance Training* Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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DK068298/DK/NIDDK NIH HHS; R01 DK068298-05/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hemoglobin A, Glycosylated; 0/hemoglobin A1c protein, human |
| Comments/Corrections | |
Comment In:
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JAMA. 2010 Nov 24;304(20):2298-9
[PMID:
21098777
]
JAMA. 2011 Mar 2;305(9):891; author reply 891-2 [PMID: 21364137 ] |
Erratum In:
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JAMA. 2011 Mar 2;305(9):892 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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