Document Detail


Effects of aerobic and resistance training on hemoglobin A1c levels in patients with type 2 diabetes: a randomized controlled trial.
MedLine Citation:
PMID:  21098771     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONTEXT: Exercise guidelines for individuals with diabetes include both aerobic and resistance training although few studies have directly examined this exercise combination.
OBJECTIVE: To examine the benefits of aerobic training alone, resistance training alone, and a combination of both on hemoglobin A(1c) (HbA(1c)) in individuals with type 2 diabetes.
DESIGN, SETTING, AND PARTICIPANTS: A randomized controlled trial in which 262 sedentary men and women in Louisiana with type 2 diabetes and HbA(1c) levels of 6.5% or higher were enrolled in the 9-month exercise program between April 2007 and August 2009.
INTERVENTION: Forty-one participants were assigned to the nonexercise control group, 73 to resistance training 3 days a week, 72 to aerobic exercise in which they expended 12 kcal/kg per week; and 76 to combined aerobic and resistance training in which they expended 10 kcal/kg per week and engaged in resistance training twice a week. Main Outcome Change in HbA(1c) level. Secondary outcomes included measures of anthropometry and fitness.
RESULTS: The study included 63.0% women and 47.3% nonwhite participants who were a mean (SD) age of 55.8 years (8.7 years) with a baseline HbA(1c) level of 7.7% (1.0%). Compared with the control group, the absolute mean change in HbA(1c) in the combination training exercise group was -0.34% (95% confidence interval [CI], -0.64% to -0.03%; P = .03). The mean changes in HbA(1c) were not statistically significant in either the resistance training (-0.16%; 95% CI, -0.46% to 0.15%; P = .32) or the aerobic (-0.24%; 95% CI, -0.55% to 0.07%; P = .14) groups compared with the control group. Only the combination exercise group improved maximum oxygen consumption (mean, 1.0 mL/kg per min; 95% CI, 0.5-1.5, P < .05) compared with the control group. All exercise groups reduced waist circumference from -1.9 to -2.8 cm compared with the control group. The resistance training group lost a mean of -1.4 kg fat mass (95% CI, -2.0 to -0.7 kg; P < .05) and combination training group lost a mean of -1.7 (-2.3 to -1.1 kg; P < .05) compared with the control group.
CONCLUSIONS: Among patients with type 2 diabetes mellitus, a combination of aerobic and resistance training compared with the nonexercise control group improved HbA(1c) levels. This was not achieved by aerobic or resistance training alone.
TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00458133.
Authors:
Timothy S Church; Steven N Blair; Shannon Cocreham; Neil Johannsen; William Johnson; Kimberly Kramer; Catherine R Mikus; Valerie Myers; Melissa Nauta; Ruben Q Rodarte; Lauren Sparks; Angela Thompson; Conrad P Earnest
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  JAMA     Volume:  304     ISSN:  1538-3598     ISO Abbreviation:  JAMA     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-24     Completed Date:  2010-11-29     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2253-62     Citation Subset:  AIM; IM    
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00458133
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MeSH Terms
Descriptor/Qualifier:
Anthropometry
Diabetes Mellitus, Type 2 / blood*,  therapy*
Exercise Therapy*
Female
Hemoglobin A, Glycosylated / analysis*
Humans
Male
Middle Aged
Physical Fitness
Resistance Training*
Treatment Outcome
Grant Support
ID/Acronym/Agency:
DK068298/DK/NIDDK NIH HHS; R01 DK068298-05/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Hemoglobin A, Glycosylated; 0/hemoglobin A1c protein, human
Comments/Corrections
Comment In:
JAMA. 2010 Nov 24;304(20):2298-9   [PMID:  21098777 ]
JAMA. 2011 Mar 2;305(9):891; author reply 891-2   [PMID:  21364137 ]
Erratum In:
JAMA. 2011 Mar 2;305(9):892

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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