| Effects of aerobic exercise training on indices of ventricular repolarization in patients with chronic heart failure. | |
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MedLine Citation:
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PMID: 10424508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Patients with chronic heart failure (CHF) have a markedly increased incidence of malignant ventricular arrhythmias. QT dispersion (QTd), defined as the difference between maximal and minimal QT intervals, reflects the regional inhomogeneity of ventricular repolarization dispersion and may mark the presence of malignant ventricular arrhythmias. PURPOSE: To determine the effects of exercise training on QTd in patients with CHF. PATIENTS: Fifteen patients with CHF and ejection fractions < 40% (mean, 28+/-9%) who were on a stable medical regimen. DESIGN AND INTERVENTION: Standardized 12-lead surface ECGs were obtained at the beginning and end of the exercise training program, and QT and JT intervals were measured manually and corrected for heart rate by using Bazett's formula. QTd, heart rate-corrected QTd (QTc-d), JT dispersion (JTd), and heart rate-corrected JTd (JTc-d) were measured in at least eight ECG leads in each patient. RESULTS: Following the cardiac rehabilitation and exercise training programs, patients with CHF had only slight improvements in exercise capacity (results were not significant). However, these patients had marked improvements in QTd (71+/-11 to 59+/-17 ms; p < 0.02), QTc-d (82+/-28 to 63+/-17 ms; p < 0.01), JTd (76+/-19 to 57+/-18 ms; p < 0.002), and JTc-d (84+/-23 to 61+/-18 ms; p < 0.001) following the exercise training programs. CONCLUSION: These data indicate that aerobic exercise training significantly reduces the indices of ventricular repolarization dispersion in patients with CHF. Further studies are needed to evaluate how effectively this reduction in ventricular repolarization dispersion decreases the risk of malignant ventricular arrhythmias and sudden death in patients with CHF. |
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Authors:
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A Ali; M R Mehra; F S Malik; C J Lavie; D Bass; R V Milani |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chest Volume: 116 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 1999 Jul |
Date Detail:
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Created Date: 1999-08-16 Completed Date: 1999-08-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 83-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiology, Ochsner Medical Institutions, New Orleans, LA, USA. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Arrhythmias, Cardiac / prevention & control* Cohort Studies Electrocardiography Exercise* Exercise Tolerance / physiology Female Heart Conduction System / physiopathology Heart Failure / physiopathology, rehabilitation* Humans Male |
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