Document Detail

Effects of aerobic exercise on metabolic syndrome improvement in response to weight reduction.
MedLine Citation:
PMID:  17925474     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The objective was to test effects of aerobic exercise training on metabolic syndrome (MetSyn) improvement in response to weight reduction. RESEARCH METHODS AND PROCEDURES: A total of 459 overweight and obese women (age, 49 +/- 9 years; BMI, 28 +/- 3 kg/m(2)) were recruited for a baseline examination to test the relationship between cardiorespiratory fitness and metabolic syndrome prevalence; among these, 67 subjects with MetSyn were treated with 14-week weight-loss programs, which included low-calorie diet and aerobic exercise. The MetSyn was defined according to the Examination Committee of Criteria for "Metabolic Syndrome" in Japan. Maximal oxygen uptake (Vo(2max)) during a maximal cycling test was measured as an index of cardiorespiratory fitness at baseline and after the intervention. RESULTS: In the baseline examination, age- and BMI-adjusted odds ratios for MetSyn prevalence in the low, middle, and upper thirds of Vo(2max) were 1.0 (referent), 0.50 (95% confidence interval, 0.26 to 0.95), and 0.39 (95% confidence interval, 0.14 to 0.96), respectively (linear trend, p = 0.02). The adjusted odds ratios for MetSyn improvement in the two interventions with diet alone and diet plus exercise were 1.0 and 3.68 (95% confidence interval, 1.02 to 17.6; p = 0.04), respectively. DISCUSSION: These results suggest that adding aerobic exercise training to a dietary weight-reduction program further improves MetSyn (adjusted odds ratio, 3.68) in obese women, compared with diet alone. Further studies on an association between Vo(2max) change and MetSyn improvement are needed.
Tomohiro Okura; Yoshio Nakata; Kazunori Ohkawara; Shigeharu Numao; Yasutomi Katayama; Tomoaki Matsuo; Kiyoji Tanaka
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  15     ISSN:  1930-7381     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-10     Completed Date:  2008-01-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2478-84     Citation Subset:  IM    
Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
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MeSH Terms
Asian Continental Ancestry Group
Blood Glucose / analysis
Body Mass Index
Lipids / blood
Metabolic Syndrome X / complications,  diet therapy,  therapy*
Middle Aged
Obesity / complications,  diet therapy,  therapy*
Treatment Outcome
Weight Loss*
Reg. No./Substance:
0/Blood Glucose; 0/Lipids

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