Document Detail


Effects of aerobic exercise on chronic allergic airway inflammation and remodeling in guinea pigs.
MedLine Citation:
PMID:  22633937     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We evaluated the effects of aerobic exercise (AE) on airway inflammation, exhaled nitric oxide levels (ENO), airway remodeling, and the expression of Th1, Th2 and regulatory cytokines in a guinea pig asthma model. Animals were divided into 4 groups: non-trained and non-sensitized (C), non-sensitized and AE (AE), ovalbumin-sensitized and non-trained (OVA), and OVA-sensitized and AE (OVA+AE). OVA inhalation was performed for 8 weeks, and AE was conducted for 6 weeks beginning in the 3(rd) week of OVA sensitization. Compared to the other groups, the OVA+AE group had a reduced density of eosinophils and lymphocytes, reduced expression of interleukin (IL)-4 and IL-13 and an increase in epithelium thickness (p<0.05). AE did not modify airway remodeling or ENO in the sensitized groups (p>0.05). Neither OVA nor AE resulted in differences in the expression of IL-2, IFN-γ, IL-10 or IL1-ra. Our results show that AE reduces the expression of Th2 cytokines and allergic airway inflammation and induces epithelium remodeling in sensitized guinea pigs.
Authors:
Clarice R Olivo; Rodolfo P Vieira; Fernanda M Arantes-Costa; Adenir Perini; Milton Arruda Martins; Celso Ricardo Fernandes Carvalho
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-23
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  -     ISSN:  1878-1519     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Affiliation:
Departments of Physical Therapy, School of Medicine, University of Sao Paulo, Av. Dr Arnaldo, 455, Room 1210, Zip code: 01246-903, São Paulo-SP, Brazil; Departments of Medicine (LIM-20), School of Medicine, University of Sao Paulo, Av. Dr Arnaldo, 455, Room 1210, Zip code: 01246-903, São Paulo-SP, Brazil.
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