Document Detail

Effects of advanced glycation endproducts on the generation of macrophage-mediated oxidized low-density lipoprotein.
MedLine Citation:
PMID:  9365875     Owner:  NLM     Status:  MEDLINE    
Macrophages have a receptor that recognizes advanced glycation endproducts (AGE). In this study, we evaluated the effect of AGEs on the generation of macrophage-mediated oxidized low-density lipoprotein (LDL) by measuring the electrophoretic mobilities and lipid hydroperoxide (LHPO) levels of LDL. In the absence of the macrophage monolayer, the differences of the electrophoretic mobilities or LHPO levels of native (n) LDL did not differ significantly between control (c) bovine serum albumin (BSA) and those with AGE-BSA. In the presence of the macrophage monolayer, however, the difference was significant with higher levels after the incubation with AGE-BSA than with c-BSA. In the case of cLDL and glycated (g) LDL, the electrophoretic mobilities and LHPO levels of LDL after 20 h incubation with AGE-BSA in the presence of the macrophage monolayer were significantly higher than those with c-BSA. There were no significant differences, however between the electrophoretic mobilities and LHPO levels of cLDL and of gLDL. These results suggest that AGEs stimulate the generation of macrophage-mediated oxidized LDL, but do not directly stimulate the oxidative modification of gLDL.
J Matsui; T Onuma; N Tamasawa; T Suda
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of diabetes and its complications     Volume:  11     ISSN:  1056-8727     ISO Abbreviation:  J. Diabetes Complicat.     Publication Date:    1997 Nov-Dec
Date Detail:
Created Date:  1998-02-05     Completed Date:  1998-02-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9204583     Medline TA:  J Diabetes Complications     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  338-42     Citation Subset:  IM    
Third Department of Internal Medicine, Hirosaki University School of Medicine, Japan.
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MeSH Terms
Electrophoresis, Agar Gel
Glycosylation End Products, Advanced / physiology*
Lipoproteins, LDL / biosynthesis*
Macrophages, Peritoneal / metabolism*
Rats, Wistar
Serum Albumin / metabolism
Reg. No./Substance:
0/Glycosylation End Products, Advanced; 0/Lipoproteins, LDL; 0/Serum Albumin

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