| Effects of adrenergic and cholinergic drugs on splenic arteries and veins from hooded seals (Cystophora cristata). | |
| | |
MedLine Citation:
|
PMID: 9773508 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Isolated ring preparations of arteries and veins from hooded seal spleens were subjected in vitro to adrenaline (A), noradrenaline (NA), isoprenaline (Iso), and acetylcholine (ACh), alone or in combination with the blockers phentolamine (Phe), propranolol (Pro), and atropine (Atr). Both arteries and veins constricted in response to A (the estimated effective dose required for half-maximal response (ED50) was 3.3 and 0.2 microM, for arteries and veins, respectively) and NA (estimated ED50 was 1.5 and 0.6 microM, for arteries and veins, respectively), but these effects were abolished when the drugs were given in combination with the alpha-adrenoceptor blocker Phe. The responses of arteries and veins to ACh and the beta-adrenoceptor agonist Iso were minor and inconsistent, and were completely abolished when combined with their respective blockers (Atr and Pro, respectively). The ED50 for both A and NA are quite high in relation to normal plasma levels of A and NA in seals. This implies that these vessels (and, hence, the supply of blood to the spleen) primarily are subjected to neurogenic, rather than humoral physiological control. |
| | |
Authors:
|
A Cabanac; L P Folkow; A S Blix |
Related Documents
:
|
8670738 - Effect of dipyridamole on vascular responses of porcine ciliary arteries. 8368368 - Neuropeptide y potentiates contractile response to norepinephrine in skate coronary art... 1849908 - Mechanism of the enhanced vasoconstrictor responses to endothelin-1 in canine cerebral ... 6141288 - Roles of extrajunctional receptors in the response of guinea-pig mesenteric and rat tai... 17019668 - Pulmonary atheroembolism via an av shunt. 15136058 - N(omega)-(carboxymethyl)lysine depositions in human aortic heart valves: similarities w... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Volume: 120 ISSN: 1095-6433 ISO Abbreviation: Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. Publication Date: 1998 Jun |
Date Detail:
|
Created Date: 1998-11-04 Completed Date: 1998-11-04 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9806096 Medline TA: Comp Biochem Physiol A Mol Integr Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 277-81 Citation Subset: IM |
Affiliation:
|
Department of Arctic Biology, University of Tromsø, Norway. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenergic Agents
/
pharmacology* Animals Cholinergic Agents / pharmacology* Female Male Seals, Earless / physiology* Splenic Artery / drug effects* Splenic Vein / drug effects* Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic Agents; 0/Cholinergic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Long-term pharmacological kindling increases in vitro release of IR-Met and IR-Leu-enkephalin from a...
Next Document: Response of the parotid gland of the brushtail possum, Trichosurus vulpecula, to adrenergic stimulat...