Document Detail

Effects of adrenergic and cholinergic drugs on splenic arteries and veins from hooded seals (Cystophora cristata).
MedLine Citation:
PMID:  9773508     Owner:  NLM     Status:  MEDLINE    
Isolated ring preparations of arteries and veins from hooded seal spleens were subjected in vitro to adrenaline (A), noradrenaline (NA), isoprenaline (Iso), and acetylcholine (ACh), alone or in combination with the blockers phentolamine (Phe), propranolol (Pro), and atropine (Atr). Both arteries and veins constricted in response to A (the estimated effective dose required for half-maximal response (ED50) was 3.3 and 0.2 microM, for arteries and veins, respectively) and NA (estimated ED50 was 1.5 and 0.6 microM, for arteries and veins, respectively), but these effects were abolished when the drugs were given in combination with the alpha-adrenoceptor blocker Phe. The responses of arteries and veins to ACh and the beta-adrenoceptor agonist Iso were minor and inconsistent, and were completely abolished when combined with their respective blockers (Atr and Pro, respectively). The ED50 for both A and NA are quite high in relation to normal plasma levels of A and NA in seals. This implies that these vessels (and, hence, the supply of blood to the spleen) primarily are subjected to neurogenic, rather than humoral physiological control.
A Cabanac; L P Folkow; A S Blix
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology     Volume:  120     ISSN:  1095-6433     ISO Abbreviation:  Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-11-04     Completed Date:  1998-11-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9806096     Medline TA:  Comp Biochem Physiol A Mol Integr Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  277-81     Citation Subset:  IM    
Department of Arctic Biology, University of Tromsø, Norway.
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MeSH Terms
Adrenergic Agents / pharmacology*
Cholinergic Agents / pharmacology*
Seals, Earless / physiology*
Splenic Artery / drug effects*
Splenic Vein / drug effects*
Vascular Resistance / drug effects
Reg. No./Substance:
0/Adrenergic Agents; 0/Cholinergic Agents

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