Document Detail

Effects of adrenergic blockade on hepatic glucose production during ethanol administration.
MedLine Citation:
PMID:  9347199     Owner:  NLM     Status:  MEDLINE    
Acute ethanol administration stimulates sympathetic nervous system activity. The present study was designed to determine whether this sympathetic activation affects glycogenolysis and total hepatic glucose production (HGP) during ethanol-induced inhibition of gluconeogenesis. Nineteen volunteers participated in four protocols. Two protocols aimed to study--using combined infusion of [6,6-2H2]glucose and [U-13C]glucose, VCO2 and 13CO2 measurements--the effects of ethanol infusion alone (n = 10) or with propranolol (n = 6) or phentolamine infusion (n = 4) on HGP, glucose disposal (Rd), glucose oxidation [13C]Glcox and non-oxidative glucose disposal (NOGD = Rd - [13C]Glcox). The fourth protocol assessed the effects of saline infusion alone on HGP. Using ethanol, HGP decreased by 23%, Rd by 20% and glycaemia by 9% (all P < 0.001); heart rate increased by 10%, whereas blood pressure remained unchanged. The effects were not observed with saline, except a slight (10%) decrease in HGP (P < 0.01 vs. ethanol). Ethanol did not affect [13C]Glcox but decreased NOGD by 73% (P < 0.001). Propranolol or phentolamine did not alter any of the effects of ethanol on glucose metabolism, but decreased mean arterial pressure. Propranolol prevented the ethanol-induced increase in heart rate. In conclusion, ethanol decreased blood glucose by decreasing HGP, presumably by inhibiting gluconeogenesis. Sympathetic activation prevented the decrease in blood pressure produced by ethanol but did not stimulate glycogenolysis.
J Delarue; P Schneiter; S Henry; C Cayeux; E Haesler; E Jéquier; L Tappy
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical physiology (Oxford, England)     Volume:  17     ISSN:  0144-5979     ISO Abbreviation:  Clin Physiol     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-12-19     Completed Date:  1997-12-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8309768     Medline TA:  Clin Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  509-21     Citation Subset:  IM    
Institute of Physiology, Faculty of Medicine, University of Lausanne, Switzerland.
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MeSH Terms
Adrenergic Antagonists / pharmacology*
Blood Glucose / metabolism
Blood Pressure / drug effects,  physiology
Ethanol / blood,  toxicity*
Fatty Acids, Nonesterified / blood
Glucagon / blood
Gluconeogenesis / drug effects
Glucose / biosynthesis*,  metabolism
Heart Rate / drug effects,  physiology
Insulin / blood
Liver / drug effects*,  metabolism*
Liver Glycogen / metabolism
Phentolamine / pharmacology
Propranolol / pharmacology
Sympathetic Nervous System / drug effects,  physiology
Reg. No./Substance:
0/Adrenergic Antagonists; 0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Liver Glycogen; 11061-68-0/Insulin; 50-60-2/Phentolamine; 50-99-7/Glucose; 525-66-6/Propranolol; 64-17-5/Ethanol; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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