Document Detail

Effects of administration of human chorionic gonadotropin or progesterone before maternal recognition of pregnancy on blastocyst development and pregnancy in sheep.
MedLine Citation:
PMID:  8157530     Owner:  NLM     Status:  MEDLINE    
A series of four experiments with 258 ewes was conducted to determine whether blastocyst size could be altered before normal luteolysis and, if so, how this affected fertility. In Exp. 1 and 2, nonmated and mated ewes, respectively, were treated with hCG (100 IU), progesterone (12 mg), or vehicle on d 11.5 (d 0 = onset of estrus). In Exp. 3 and 4, field trials were conducted to compare the effects of either hCG or progesterone treatment on d 11.5 on subsequent pregnancy rates. In Exp. 1, hCG transiently increased (P < .01) concentrations of progesterone and estradiol in plasma, whereas progesterone treatment increased only plasma progesterone. Neither hCG nor progesterone affected the duration of the estrous cycle. In Exp. 2, d-13 blastocysts were longer (3.5 +/- 1.6 vs .8 +/- .5 cm; Mean +/- SE; P < .05), and concentrations of protein and interferon tau (IFN tau) in uterine flushings were greater (10.7 vs 1.2 micrograms; P < .05) in hCG than in vehicle-treated ewes. Progesterone treatment did not affect blastocyst development. In Exp. 3, pregnancy rates tended to be greater (P < .10) in ewes given hCG than in those given vehicle (44/47; 94% vs 40/48; 83%); however, administration of progesterone in Exp. 4 had no effect on pregnancy rates (P < .14; 41/45; 91% vs 37/46; 80%; control ewes). These results indicate that treatment with hCG on d 11.5 stimulated uterine secretions and conceptus growth sufficiently to influence pregnancy rates.
K P Nephew; H Cárdenas; K E McClure; T L Ott; F W Bazer; W F Pope
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of animal science     Volume:  72     ISSN:  0021-8812     ISO Abbreviation:  J. Anim. Sci.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-05-17     Completed Date:  1994-05-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8003002     Medline TA:  J Anim Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  453-8     Citation Subset:  IM    
Department of Animal Science, Ohio State University, Columbus 43210.
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MeSH Terms
Blastocyst / drug effects*,  physiology
Chorionic Gonadotropin / pharmacology*
Corpus Luteum / drug effects
Dinoprost / metabolism
Estradiol / blood
Estrus / drug effects
Fertility / drug effects*
Progesterone / blood,  pharmacology*
Sheep / embryology,  physiology*
Reg. No./Substance:
0/Chorionic Gonadotropin; 50-28-2/Estradiol; 551-11-1/Dinoprost; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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