Document Detail

Effects of administration of growth hormone-releasing factor to sows during late gestation on growth hormone secretion, reproductive traits, and performance of progeny from birth to 100 kilograms live weight.
MedLine Citation:
PMID:  1644696     Owner:  NLM     Status:  MEDLINE    
The effects of growth hormone-releasing factor (GHRF) injections to sows during late gestation were investigated in two experiments. In the first one, four treatments were applied to eight catheterized sows according to two 4 x 4 Latin squares: oral administration of 2 mg of pyridostigmine, a cholinesterase inhibitor, per kilogram of BW (PYR group); i.m. injection of 50 micrograms of GHRF/kg BW (GHRF group); a combination of the pyridostigmine and GHRF treatments (PYR+GHRF); or i.m. injection of glucose (control). Pyridostigmine slightly increased the plasma concentration of growth hormone (GH). Growth hormone responses to GHRF and PYR+GHRF treatments were similar, with significantly elevated GH concentrations from 5 to 240 min after GHRF injection. In the second experiment, 36 sows were allocated to two treatments at 102 d of gestation. Until farrowing, they were injected twice daily with 50 micrograms of GHRF/kg BW (GHRF group) or isotonic glucose (control). The DM, N, fat, and energy content of 24 pigs per group was determined at weaning at 22 d. Six pigs per litter had ad libitum access to feed until slaughter at 100 kg BW and their carcasses were evaluated. Treatment with GHRF increased pregnancy duration (114.8 vs 113.6 d, P less than .05), weight of pigs at 13 d (3.69 vs 3.54 kg, P less than .05) and at weaning (5.74 vs 5.48 kg, P less than .05), and improved pig survival (86 vs 71%, P less than .05). Lipid (on a DM basis) and energy contents of the pigs slaughtered at weaning were significantly higher in the GHRF group than in the control group (14.4 vs 12.5% and 2,178 vs 2,029 kcal/kg, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
M Etienne; M Bonneau; G Kann; F Deletang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of animal science     Volume:  70     ISSN:  0021-8812     ISO Abbreviation:  J. Anim. Sci.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-09-10     Completed Date:  1992-09-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8003002     Medline TA:  J Anim Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2212-20     Citation Subset:  IM    
Station de Recherches Porcines, INRA, St. Gilles, Hermitage, France.
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MeSH Terms
Animals, Newborn / growth & development*
Birth Weight / drug effects
Body Composition / drug effects
Eating / drug effects
Growth Hormone / blood,  secretion*
Growth Hormone-Releasing Hormone / pharmacology*
Litter Size / drug effects
Meat / standards
Pyridostigmine Bromide / pharmacology
Reproduction / drug effects*
Sex Factors
Swine / growth & development,  metabolism*,  physiology
Weight Gain / drug effects
Reg. No./Substance:
101-26-8/Pyridostigmine Bromide; 9002-72-6/Growth Hormone; 9034-39-3/Growth Hormone-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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