| Effects of acute verjuice consumption with a high-cholesterol diet on some biochemical risk factors of atherosclerosis in rabbits. | |
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MedLine Citation:
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PMID: 20357713 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Metabolic changes in postprandial state particularly after fatty meals lead to atherosclerosis progression. Verjuice is an acidic juice made from unripe grape, commonly used as a popular ingredient in Iran. In this study the acute effects of verjuice intake on postprandial values of some biochemical atherosclerosis risk factors in rabbits fed high-cholesterol diets were investigated to see if it has is a possible protective role. MATERIAL/METHODS: Rabbits were allowed free access to diets containing: no cholesterol, 1% cholesterol, 1% cholesterol with 5 ml of verjuice, and 1% cholesterol with 10 ml of verjuice. C-reactive protein (CRP), malondialdehyde (MDA), nitrite, nitrate, glucose, LDL-cholesterol (LDL-C), oxidized-LDL (ox-LDL), total cholesterol (TC), apolipoprotein B (ApoB), triglyceride (TG), HDL-cholesterol (HDL-C), apolipoprotein A(ApoA), serum glutamic pyruvic transaminase (SGPT), serum glutamic oxaloacetate transaminase (SGOT), and fibrinogen levels were measured before and three hours after feeding these diets. RESULTS: Significant differences were observed in fibrinogen and glucose levels between the high-cholesterol diet with 5 and 10 ml verjuice and the high-cholesterol diet alone. Using 10 ml verjuice with the the high-cholesterol diet caused a significant reduction in ox-LDL, MDA, and nitrite compared with the high-cholesterol diet alone. No significant difference was found between the groups receiving verjuice and the high-cholesterol diet group in TC, HDL-C, TG, LDL-C, ApoA, ApoB, SGPT, SGOT, nitrate, or CRP. CONCLUSIONS: These results suggest that there might be an acute protective effect in the postprandial use of verjuice on some of the risk factors of atherosclerosis, particularly as an antioxidant. |
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Authors:
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Mahbubeh Setorki; Sedighe Asgary; Akram Eidi; Ali Haeri Rohani |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical science monitor : international medical journal of experimental and clinical research Volume: 16 ISSN: 1643-3750 ISO Abbreviation: Med. Sci. Monit. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-01 Completed Date: 2010-08-05 Revised Date: 2011-06-14 |
Medline Journal Info:
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Nlm Unique ID: 9609063 Medline TA: Med Sci Monit Country: Poland |
Other Details:
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Languages: eng Pagination: BR124-130 Citation Subset: IM |
Affiliation:
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Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran. doctor.setorgi@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / metabolism Atherosclerosis / etiology*, metabolism* Beverages Blood Glucose / metabolism Cholesterol / metabolism* Fibrinogen / metabolism Hydrogen-Ion Concentration Inflammation Male Malondialdehyde / metabolism Oxygen / metabolism Rabbits Risk Risk Factors Transaminases / blood Vitis / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Blood Glucose; 542-78-9/Malondialdehyde; 57-88-5/Cholesterol; 7782-44-7/Oxygen; 9001-32-5/Fibrinogen; EC 2.6.1.-/Transaminases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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