Document Detail


Effects of acute treatment with 8-OH-DPAT and fluoxetine on aggressive behaviour in male song sparrows (Melospiza melodia morphna).
MedLine Citation:
PMID:  12535157     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The role of serotonin in modulating male aggressive behaviour was investigated in male song sparrows, Melospiza melodia morphna, using two different serotonergic drugs, fluoxetine and 8-OH-DPAT. Fluoxetine is a selective serotonin reuptake inhibitor of the neuronal reuptake pump increasing synaptic concentrations of serotonin, and 8-OH-DPAT is a specific serotonin (5-HT1A) receptor agonist. The serotonergic control of aggression in passerines has not been previously investigated. We examined these behaviours within a controlled setting using a laboratory simulated territorial intrusion, with a hierarchical scale to quantify male-male aggressive behaviour. Utilizing this scale, we quantified the extent of male aggressive behaviour in two experiments. In experiment 1, song sparrows were given 100 micro l, s.c. injections of either fluoxetine (10 mg/kg) or 8-OH-DPAT (1 mg/kg). Experiment 2 was a dose-response study using three doses of 8-OH-DPAT (0.1, 1 and 10 mg/kg). In both studies, aggressive behaviour was measured 1 h after injection for 10 min in response to the presence of a novel male decoy combined with playback of conspecific song. Both drugs significantly reduced male aggressive behaviour, and 8-OH-DPAT did so in a dose-dependent manner. The effect of the two drugs upon general activity was also measured using infra-red perch hop detectors. Activity levels were not effected by either fluoxetine or 8-OH-DPAT at all of the respective doses, indicating that the reduction in aggressive behaviour was specific. These results demonstrate that, in a passerine species, the serotonergic system negatively regulates male-male aggressive behaviour. These results further demonstrate that aggression can be effectively studied in a laboratory setting and natural aggressive responses can be elicited using this method.
Authors:
T S Sperry; C K Thompson; J C Wingfield
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neuroendocrinology     Volume:  15     ISSN:  0953-8194     ISO Abbreviation:  J. Neuroendocrinol.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-01-21     Completed Date:  2003-03-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8913461     Medline TA:  J Neuroendocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  150-60     Citation Subset:  IM    
Affiliation:
Department of Zoology, University of Washington, Seattle, WA 98195, USA. tsperry@u.washington.edu
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MeSH Terms
Descriptor/Qualifier:
8-Hydroxy-2-(di-n-propylamino)tetralin / pharmacology*
Aggression / drug effects*
Animals
Behavior, Animal / drug effects
Fluoxetine / pharmacology*
Male
Serotonin Agonists / pharmacology*
Serotonin Uptake Inhibitors / pharmacology*
Songbirds
Grant Support
ID/Acronym/Agency:
MH12986-01/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Serotonin Agonists; 0/Serotonin Uptake Inhibitors; 54910-89-3/Fluoxetine; 78950-78-4/8-Hydroxy-2-(di-n-propylamino)tetralin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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