Document Detail


Effects of acute and sub-chronic nicotine on impulsive choice in rats in a probabilistic delay-discounting task.
MedLine Citation:
PMID:  23340981     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE: Cigarette smokers typically display impulsivity by preferring immediate rewards over larger, delayed rewards at shorter delays than do non-smokers. Suggesting causality, nicotine injections in rats increase the choice for an immediate reward over a larger, delayed reward.
OBJECTIVES: To examine the generality of this latter effect, the present study employed a delay-discounting task to determine if acute and sub-chronic nicotine will also increase impulsive choice when subjective reward value is manipulated by changes in the probability, rather than magnitude, of reward.
MATERIALS AND METHODS: Rats were presented with two levers, one of which delivered an immediate water reward on half of the trials, while the other lever delivered the same reward on every trial, but only after one of five increasing delays.
RESULTS: Acute injections of 1.2 mg/kg, but not 0.8 mg/kg, of nicotine increased the preference for the immediate (but less certain) reward lever at intermediate delays. Moreover, twice-daily injections of 0.8 mg/kg of nicotine for 6 days progressively increased the preference for the immediate reward. Latency to make the first response on each trial was not affected by nicotine.
CONCLUSIONS: The similar increases in impulsive choice produced by both acute and sub-chronic nicotine in delay-discounting paradigms whether subjective reward value is manipulated by changes in reward magnitude or probability suggests that nicotine may be increasing what is common to these paradigms, namely delay discounting. Whatever the mechanism, these data indicate that both acute and sub-chronic nicotine may help develop and maintain an addiction by increasing impulsivity.
Authors:
John E Kelsey; Anzela Niraula
Publication Detail:
Type:  Journal Article     Date:  2013-01-23
Journal Detail:
Title:  Psychopharmacology     Volume:  227     ISSN:  1432-2072     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-16     Completed Date:  2013-12-13     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  385-92     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal
Choice Behavior / drug effects*
Conditioning, Operant
Impulsive Behavior / drug therapy*,  psychology
Male
Nicotine / administration & dosage,  pharmacology*
Probability
Rats
Rats, Long-Evans
Reaction Time
Reinforcement Schedule*
Reward*
Time Factors
Chemical
Reg. No./Substance:
54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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