Document Detail

Effects of acute stress, relaxation, and a neurogenic inflammatory stimulus on interleukin-6 in humans.
MedLine Citation:
PMID:  14651947     Owner:  NLM     Status:  MEDLINE    
Effects of three experimental manipulations: mental stress, relaxation, and a nociceptive inflammatory stimulus, capsaicin, on levels of interleukin-6 (IL-6) were examined. Fifty subjects were pre-trained in relaxation and then randomized to a stress (Stroop test), relaxation (tape), or control (video) manipulation. Subjects participated in an evening reactivity session including 20 min of stress, relaxation, or control followed by a capsaicin injection in the forearm. Cardiovascular variables and levels of IL-6 were measured before and after the manipulation, and at regular intervals up to 60 min post-capsaicin. Group assignment did not differentially affect change in IL-6 over time, either before or after capsaicin. Small but significant increases in IL-6 were seen at 60 min post-capsaicin. These findings suggest that an acute stress manipulation does not modulate IL-6 within this time frame. Although IL-6 did increase following a neurogenic inflammatory stimulus, it did so subsequent to the maximum flare, suggesting that flare mechanisms are independent of IL-6.
Susan K Lutgendorf; Henrietta Logan; Erin Costanzo; David Lubaroff
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain, behavior, and immunity     Volume:  18     ISSN:  0889-1591     ISO Abbreviation:  Brain Behav. Immun.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-03     Completed Date:  2004-03-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8800478     Medline TA:  Brain Behav Immun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  55-64     Citation Subset:  IM    
Department of Psychology, E11 Seashore Hall, University of Iowa, Iowa City, IA 52242, USA.
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MeSH Terms
Capsaicin / immunology*
Dermatitis, Irritant / immunology*
Interleukin-6 / blood*,  immunology
Irritants / immunology*
Reference Values
Relaxation / physiology*,  psychology
Stress, Psychological / blood*
Grant Support
Reg. No./Substance:
0/Interleukin-6; 0/Irritants; 404-86-4/Capsaicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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