| Effects of acute stress, relaxation, and a neurogenic inflammatory stimulus on interleukin-6 in humans. | |
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MedLine Citation:
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PMID: 14651947 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Effects of three experimental manipulations: mental stress, relaxation, and a nociceptive inflammatory stimulus, capsaicin, on levels of interleukin-6 (IL-6) were examined. Fifty subjects were pre-trained in relaxation and then randomized to a stress (Stroop test), relaxation (tape), or control (video) manipulation. Subjects participated in an evening reactivity session including 20 min of stress, relaxation, or control followed by a capsaicin injection in the forearm. Cardiovascular variables and levels of IL-6 were measured before and after the manipulation, and at regular intervals up to 60 min post-capsaicin. Group assignment did not differentially affect change in IL-6 over time, either before or after capsaicin. Small but significant increases in IL-6 were seen at 60 min post-capsaicin. These findings suggest that an acute stress manipulation does not modulate IL-6 within this time frame. Although IL-6 did increase following a neurogenic inflammatory stimulus, it did so subsequent to the maximum flare, suggesting that flare mechanisms are independent of IL-6. |
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Authors:
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Susan K Lutgendorf; Henrietta Logan; Erin Costanzo; David Lubaroff |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain, behavior, and immunity Volume: 18 ISSN: 0889-1591 ISO Abbreviation: Brain Behav. Immun. Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2003-12-03 Completed Date: 2004-03-01 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8800478 Medline TA: Brain Behav Immun Country: United States |
Other Details:
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Languages: eng Pagination: 55-64 Citation Subset: IM |
Affiliation:
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Department of Psychology, E11 Seashore Hall, University of Iowa, Iowa City, IA 52242, USA. susan-lutgendorf@uiowa.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Capsaicin / immunology* Dermatitis, Irritant / immunology* Female Humans Interleukin-6 / blood*, immunology Irritants / immunology* Male Reference Values Relaxation / physiology*, psychology Stress, Psychological / blood* |
| Grant Support | |
ID/Acronym/Agency:
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RR00059/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6; 0/Irritants; 404-86-4/Capsaicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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