Document Detail

Effects of acute and repeated ethanol exposures on the locomotor activity of BXD recombinant inbred mice.
MedLine Citation:
PMID:  7625557     Owner:  NLM     Status:  MEDLINE    
Investigations of ethanol's (EtOH's) complex response profile, including locomotor and other effects, are likely to lead to a more in-depth understanding of the constituents of alcohol addiction. Locomotor activity responses to acute and repeated EtOH (2 g/kg, ip) exposures were measured in BXD recombinant inbred (RI) mice and their C57BL/6J (B6) and DBA/2J (D2) progenitors. Both the acute response and the change in initial EtOH response with repeated treatments were strain-dependent. The coefficient of genetic determination was 0.38-0.49 for initial locomotor response to EtOH, and 0.29 for change in response. Changes in response were largely attributable to sensitization of locomotor stimulation. Quantitative trait loci (QTL) analyses identified significant marker associations with basal activity, acute locomotor response, and change in response. Markers were for QTL on several chromosomes, and there was only one case of overlap in marker associations among phenotypes. Acute locomotor response and locomotor sensitization were negatively correlated with 3% EtOH preference drinking data collected in BXD RI strains. Overall, these results demonstrate locomotor sensitization induced by EtOH, suggest independence of genetic determination of locomotor responses to acute and repeated EtOH exposure, and partially support a relationship between reduced sensitivity to the locomotor stimulant/sensitizing effects of EtOH and EtOH consumption.
T J Phillips; M Huson; C Gwiazdon; S Burkhart-Kasch; E H Shen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Alcoholism, clinical and experimental research     Volume:  19     ISSN:  0145-6008     ISO Abbreviation:  Alcohol. Clin. Exp. Res.     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-08-29     Completed Date:  1995-08-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7707242     Medline TA:  Alcohol Clin Exp Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  269-78     Citation Subset:  IM    
Veterans Affairs Medical Center, Portland, OR 97201, USA.
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MeSH Terms
Alcoholism / genetics*
Association Learning / drug effects
Chromosome Mapping
Conditioning (Psychology) / drug effects
Dose-Response Relationship, Drug
Ethanol / pharmacology*
Genetic Markers / genetics
Injections, Intraperitoneal
Mice, Inbred Strains
Motor Activity / drug effects*,  genetics*
Recombination, Genetic
Species Specificity
Stereotyped Behavior / drug effects
X Chromosome
Grant Support
Reg. No./Substance:
0/Genetic Markers; 64-17-5/Ethanol

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