| Effects of acute and repeated administration of a cholinesterase inhibitor on timing behaviour. | |
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MedLine Citation:
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PMID: 15163438 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been hypothesised that a leftward shift in the response distribution obtained in the peak interval (PI) procedure is a characteristic of cognitive enhancement in which mental processes are speeded. Metrifonate, a cholinesterase inhibitor with reported cognitive enhancing properties in many animal models of learning and memory, was tested in the PI procedure. Acute administration of 3 and 60 mg/kg but not 1 and 30 mg/kg in fully trained rats shifted the response distribution to the right, whereas subchronic administration of 10, 30 or 50 mg/kg during task acquisition had no effect on timing behaviour. On the basis of the present data, it can be concluded that the effects of a cognition enhancer in the PI procedure cannot be predicted from the scalar expectancy theory (SET). Furthermore, SET does not appear to be an appropriate tool for analysing the acquisition of timing behaviour. |
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Authors:
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Pascale C Bouger; Laura Spowart-Manning; Andre Ferrara; Bernard H Schmidt; Franz-Josef van der Staay |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology Volume: 14 ISSN: 0924-977X ISO Abbreviation: Eur Neuropsychopharmacol Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-05-27 Completed Date: 2004-09-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9111390 Medline TA: Eur Neuropsychopharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 285-94 Citation Subset: IM |
Affiliation:
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CNS Research, Bayer AG, Aprather Weg 18a, D-42096 Wuppertal, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal / drug effects* Cholinesterase Inhibitors / pharmacology* Discrimination (Psychology) / drug effects Dose-Response Relationship, Drug Drug Administration Schedule Male Mental Processes / drug effects* Models, Psychological Rats Time Perception / drug effects* Trichlorfon / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Cholinesterase Inhibitors; 52-68-6/Trichlorfon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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